Abstract
Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.
| Original language | English |
|---|---|
| Title of host publication | AIP Conference Proceedings |
| Publisher | American Institute of Physics Inc. |
| Pages | 31-34 |
| Number of pages | 4 |
| Volume | 1623 |
| ISBN (Print) | 9780735412606 |
| DOIs | |
| Publication status | Published - 2014 |
| Event | International Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Russian Federation Duration: 3 Sep 2014 → 5 Sep 2014 |
Other
| Other | International Conference on Physical Mesomechanics of Multilevel Systems 2014 |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 3.9.14 → 5.9.14 |
Fingerprint
Keywords
- Acute toxicity
- Chronic toxicity
- Hybrid material
- Local irritative effect
- Low-dimensional structures of aluminum oxide
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. / Bakina, Olga V.; Glazkova, Elena A.; Svarovskaya, Natalia Valentinovna; Lozhkomoev, Aleksandr S.; Dygay, Aleksandr M.; Churin, Aleksey A.; Lerner, Marat Izrailevich; Psakhie, Sergey G.
AIP Conference Proceedings. Vol. 1623 American Institute of Physics Inc., 2014. p. 31-34.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide
AU - Bakina, Olga V.
AU - Glazkova, Elena A.
AU - Svarovskaya, Natalia Valentinovna
AU - Lozhkomoev, Aleksandr S.
AU - Dygay, Aleksandr M.
AU - Churin, Aleksey A.
AU - Lerner, Marat Izrailevich
AU - Psakhie, Sergey G.
PY - 2014
Y1 - 2014
N2 - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.
AB - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.
KW - Acute toxicity
KW - Chronic toxicity
KW - Hybrid material
KW - Local irritative effect
KW - Low-dimensional structures of aluminum oxide
UR - http://www.scopus.com/inward/record.url?scp=84915731555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84915731555&partnerID=8YFLogxK
U2 - 10.1063/1.4901475
DO - 10.1063/1.4901475
M3 - Conference contribution
AN - SCOPUS:84915731555
SN - 9780735412606
VL - 1623
SP - 31
EP - 34
BT - AIP Conference Proceedings
PB - American Institute of Physics Inc.
ER -