Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide

Olga V. Bakina, Elena A. Glazkova, Natalia Valentinovna Svarovskaya, Aleksandr S. Lozhkomoev, Aleksandr M. Dygay, Aleksey A. Churin, Marat Izrailevich Lerner, Sergey G. Psakhie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
Pages31-34
Number of pages4
Volume1623
ISBN (Print)9780735412606
DOIs
Publication statusPublished - 2014
EventInternational Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Russian Federation
Duration: 3 Sep 20145 Sep 2014

Other

OtherInternational Conference on Physical Mesomechanics of Multilevel Systems 2014
CountryRussian Federation
CityTomsk
Period3.9.145.9.14

Fingerprint

toxicity
aluminum oxides
animals
irritation
absorbents
bears
adsorbents
medicine
death
organs
rats
microscopy
dosage
fibers
causes
polymers

Keywords

  • Acute toxicity
  • Chronic toxicity
  • Hybrid material
  • Local irritative effect
  • Low-dimensional structures of aluminum oxide

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Bakina, O. V., Glazkova, E. A., Svarovskaya, N. V., Lozhkomoev, A. S., Dygay, A. M., Churin, A. A., ... Psakhie, S. G. (2014). Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. In AIP Conference Proceedings (Vol. 1623, pp. 31-34). American Institute of Physics Inc.. https://doi.org/10.1063/1.4901475

Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. / Bakina, Olga V.; Glazkova, Elena A.; Svarovskaya, Natalia Valentinovna; Lozhkomoev, Aleksandr S.; Dygay, Aleksandr M.; Churin, Aleksey A.; Lerner, Marat Izrailevich; Psakhie, Sergey G.

AIP Conference Proceedings. Vol. 1623 American Institute of Physics Inc., 2014. p. 31-34.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bakina, OV, Glazkova, EA, Svarovskaya, NV, Lozhkomoev, AS, Dygay, AM, Churin, AA, Lerner, MI & Psakhie, SG 2014, Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. in AIP Conference Proceedings. vol. 1623, American Institute of Physics Inc., pp. 31-34, International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russian Federation, 3.9.14. https://doi.org/10.1063/1.4901475
Bakina OV, Glazkova EA, Svarovskaya NV, Lozhkomoev AS, Dygay AM, Churin AA et al. Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. In AIP Conference Proceedings. Vol. 1623. American Institute of Physics Inc. 2014. p. 31-34 https://doi.org/10.1063/1.4901475
Bakina, Olga V. ; Glazkova, Elena A. ; Svarovskaya, Natalia Valentinovna ; Lozhkomoev, Aleksandr S. ; Dygay, Aleksandr M. ; Churin, Aleksey A. ; Lerner, Marat Izrailevich ; Psakhie, Sergey G. / Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. AIP Conference Proceedings. Vol. 1623 American Institute of Physics Inc., 2014. pp. 31-34
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AU - Dygay, Aleksandr M.

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AB - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

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