Abstract
Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.
Original language | English |
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Title of host publication | AIP Conference Proceedings |
Publisher | American Institute of Physics Inc. |
Pages | 31-34 |
Number of pages | 4 |
Volume | 1623 |
ISBN (Print) | 9780735412606 |
DOIs | |
Publication status | Published - 2014 |
Event | International Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Russian Federation Duration: 3 Sep 2014 → 5 Sep 2014 |
Other
Other | International Conference on Physical Mesomechanics of Multilevel Systems 2014 |
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Country | Russian Federation |
City | Tomsk |
Period | 3.9.14 → 5.9.14 |
Keywords
- Acute toxicity
- Chronic toxicity
- Hybrid material
- Local irritative effect
- Low-dimensional structures of aluminum oxide
ASJC Scopus subject areas
- Physics and Astronomy(all)