Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide

Abstract

Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

Original language	English
Title of host publication	AIP Conference Proceedings
Publisher	American Institute of Physics Inc.
Pages	31-34
Number of pages	4
Volume	1623
ISBN (Print)	9780735412606
DOIs	https://doi.org/10.1063/1.4901475
Publication status	Published - 2014
Event	International Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Russian Federation Duration: 3 Sep 2014 → 5 Sep 2014

Other

Other	International Conference on Physical Mesomechanics of Multilevel Systems 2014
Country	Russian Federation
City	Tomsk
Period	3.9.14 → 5.9.14

Keywords

Acute toxicity
Chronic toxicity
Hybrid material
Local irritative effect
Low-dimensional structures of aluminum oxide

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1063/1.4901475

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Bakina, O. V., Glazkova, E. A., Svarovskaya, N. V., Lozhkomoev, A. S., Dygay, A. M., Churin, A. A., Lerner, M. I., & Psakhie, S. G. (2014). Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. In AIP Conference Proceedings (Vol. 1623, pp. 31-34). American Institute of Physics Inc.. https://doi.org/10.1063/1.4901475

Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. / Bakina, Olga V.; Glazkova, Elena A.; Svarovskaya, Natalia Valentinovna; Lozhkomoev, Aleksandr S.; Dygay, Aleksandr M.; Churin, Aleksey A.; Lerner, Marat Izrailevich; Psakhie, Sergey G.

AIP Conference Proceedings. Vol. 1623 American Institute of Physics Inc., 2014. p. 31-34.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bakina, OV, Glazkova, EA, Svarovskaya, NV, Lozhkomoev, AS, Dygay, AM, Churin, AA, Lerner, MI & Psakhie, SG 2014, Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. in AIP Conference Proceedings. vol. 1623, American Institute of Physics Inc., pp. 31-34, International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russian Federation, 3.9.14. https://doi.org/10.1063/1.4901475

Bakina, Olga V. ; Glazkova, Elena A. ; Svarovskaya, Natalia Valentinovna ; Lozhkomoev, Aleksandr S. ; Dygay, Aleksandr M. ; Churin, Aleksey A. ; Lerner, Marat Izrailevich ; Psakhie, Sergey G. / Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. AIP Conference Proceedings. Vol. 1623 American Institute of Physics Inc., 2014. pp. 31-34

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title = "Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide",

abstract = "Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.",

keywords = "Acute toxicity, Chronic toxicity, Hybrid material, Local irritative effect, Low-dimensional structures of aluminum oxide",

author = "Bakina, {Olga V.} and Glazkova, {Elena A.} and Svarovskaya, {Natalia Valentinovna} and Lozhkomoev, {Aleksandr S.} and Dygay, {Aleksandr M.} and Churin, {Aleksey A.} and Lerner, {Marat Izrailevich} and Psakhie, {Sergey G.}",

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doi = "10.1063/1.4901475",

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AU - Bakina, Olga V.

AU - Glazkova, Elena A.

AU - Svarovskaya, Natalia Valentinovna

AU - Lozhkomoev, Aleksandr S.

AU - Dygay, Aleksandr M.

AU - Churin, Aleksey A.

AU - Lerner, Marat Izrailevich

AU - Psakhie, Sergey G.

PY - 2014

Y1 - 2014

N2 - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

AB - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

KW - Acute toxicity

KW - Chronic toxicity

KW - Hybrid material

KW - Local irritative effect

KW - Low-dimensional structures of aluminum oxide

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