Abstract
Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.
| Original language | English |
|---|---|
| Pages (from-to) | 123-126 |
| Number of pages | 4 |
| Journal | Neuropsychobiology |
| Volume | 56 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Feb 2008 |
Fingerprint
Keywords
- Depression
- NEO Five-Factor Inventory
- Neuroticism
- Thyroid function
- Thyroid-stimulating hormone
- Thyrotropin
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
- Psychology(all)
Cite this
Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. / Frey, Andreas; Lampert, Angelika; Dietz, Klaus; Striebich, Sarah; Locher, Christoph; Fedorenko, Olga; Möhle, Robert; Gallinat, Jürgen; Lang, Florian; Lang, Undine E.
In: Neuropsychobiology, Vol. 56, No. 2-3, 02.2008, p. 123-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits
AU - Frey, Andreas
AU - Lampert, Angelika
AU - Dietz, Klaus
AU - Striebich, Sarah
AU - Locher, Christoph
AU - Fedorenko, Olga
AU - Möhle, Robert
AU - Gallinat, Jürgen
AU - Lang, Florian
AU - Lang, Undine E.
PY - 2008/2
Y1 - 2008/2
N2 - Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.
AB - Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.
KW - Depression
KW - NEO Five-Factor Inventory
KW - Neuroticism
KW - Thyroid function
KW - Thyroid-stimulating hormone
KW - Thyrotropin
UR - http://www.scopus.com/inward/record.url?scp=40349116633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40349116633&partnerID=8YFLogxK
U2 - 10.1159/000112954
DO - 10.1159/000112954
M3 - Article
C2 - 18182832
AN - SCOPUS:40349116633
VL - 56
SP - 123
EP - 126
JO - Neuropsychobiology
JF - Neuropsychobiology
SN - 0302-282X
IS - 2-3
ER -