Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits

Andreas Frey, Angelika Lampert, Klaus Dietz, Sarah Striebich, Christoph Locher, Olga Fedorenko, Robert Möhle, Jürgen Gallinat, Florian Lang, Undine E. Lang

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Abstract

Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Neuropsychobiology
Volume	56
Issue number	2-3
DOIs	https://doi.org/10.1159/000112954
Publication status	Published - Feb 2008

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Keywords

Depression
NEO Five-Factor Inventory
Neuroticism
Thyroid function
Thyroid-stimulating hormone
Thyrotropin

ASJC Scopus subject areas

Psychiatry and Mental health
Neuroscience(all)
Psychology(all)

Cite this

Frey, A., Lampert, A., Dietz, K., Striebich, S., Locher, C., Fedorenko, O., ... Lang, U. E. (2008). Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychobiology, 56(2-3), 123-126. https://doi.org/10.1159/000112954

Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. / Frey, Andreas; Lampert, Angelika; Dietz, Klaus; Striebich, Sarah; Locher, Christoph; Fedorenko, Olga; Möhle, Robert; Gallinat, Jürgen; Lang, Florian; Lang, Undine E.

In: Neuropsychobiology, Vol. 56, No. 2-3, 02.2008, p. 123-126.

Research output: Contribution to journal › Article

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10.1159/000112954