Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits

Abstract

Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Neuropsychobiology
Volume	56
Issue number	2-3
DOIs	https://doi.org/10.1159/000112954
Publication status	Published - Feb 2008

Keywords

Depression
NEO Five-Factor Inventory
Neuroticism
Thyroid function
Thyroid-stimulating hormone
Thyrotropin

ASJC Scopus subject areas

Psychiatry and Mental health
Neuroscience(all)
Psychology(all)

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Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. / Frey, Andreas; Lampert, Angelika; Dietz, Klaus; Striebich, Sarah; Locher, Christoph; Fedorenko, Olga; Möhle, Robert; Gallinat, Jürgen; Lang, Florian; Lang, Undine E.

In: Neuropsychobiology, Vol. 56, No. 2-3, 02.2008, p. 123-126.

Research output: Contribution to journal › Article › peer-review

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title = "Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits",

abstract = "Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.",

keywords = "Depression, NEO Five-Factor Inventory, Neuroticism, Thyroid function, Thyroid-stimulating hormone, Thyrotropin",

author = "Andreas Frey and Angelika Lampert and Klaus Dietz and Sarah Striebich and Christoph Locher and Olga Fedorenko and Robert M{\"o}hle and J{\"u}rgen Gallinat and Florian Lang and Lang, {Undine E.}",

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AU - Frey, Andreas

AU - Lampert, Angelika

AU - Dietz, Klaus

AU - Striebich, Sarah

AU - Locher, Christoph

AU - Fedorenko, Olga

AU - Möhle, Robert

AU - Gallinat, Jürgen

AU - Lang, Florian

AU - Lang, Undine E.

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