Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits

Andreas Frey, Angelika Lampert, Klaus Dietz, Sarah Striebich, Christoph Locher, Olga Fedorenko, Robert Möhle, Jürgen Gallinat, Florian Lang, Undine E. Lang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalNeuropsychobiology
Volume56
Issue number2-3
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Thyrotropin
Personality
Healthy Volunteers
Depression
Serum
Equipment and Supplies
Normal Distribution
Mood Disorders
Thyroid Gland
Neuroticism

Keywords

  • Depression
  • NEO Five-Factor Inventory
  • Neuroticism
  • Thyroid function
  • Thyroid-stimulating hormone
  • Thyrotropin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. / Frey, Andreas; Lampert, Angelika; Dietz, Klaus; Striebich, Sarah; Locher, Christoph; Fedorenko, Olga; Möhle, Robert; Gallinat, Jürgen; Lang, Florian; Lang, Undine E.

In: Neuropsychobiology, Vol. 56, No. 2-3, 02.2008, p. 123-126.

Research output: Contribution to journalArticle

Frey, A, Lampert, A, Dietz, K, Striebich, S, Locher, C, Fedorenko, O, Möhle, R, Gallinat, J, Lang, F & Lang, UE 2008, 'Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits', Neuropsychobiology, vol. 56, no. 2-3, pp. 123-126. https://doi.org/10.1159/000112954
Frey, Andreas ; Lampert, Angelika ; Dietz, Klaus ; Striebich, Sarah ; Locher, Christoph ; Fedorenko, Olga ; Möhle, Robert ; Gallinat, Jürgen ; Lang, Florian ; Lang, Undine E. / Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. In: Neuropsychobiology. 2008 ; Vol. 56, No. 2-3. pp. 123-126.
@article{fe3ca3aa83494ae6ac8b503deac77f10,
title = "Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits",
abstract = "Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.",
keywords = "Depression, NEO Five-Factor Inventory, Neuroticism, Thyroid function, Thyroid-stimulating hormone, Thyrotropin",
author = "Andreas Frey and Angelika Lampert and Klaus Dietz and Sarah Striebich and Christoph Locher and Olga Fedorenko and Robert M{\"o}hle and J{\"u}rgen Gallinat and Florian Lang and Lang, {Undine E.}",
year = "2008",
month = "2",
doi = "10.1159/000112954",
language = "English",
volume = "56",
pages = "123--126",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "2-3",

}

TY - JOUR

T1 - Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits

AU - Frey, Andreas

AU - Lampert, Angelika

AU - Dietz, Klaus

AU - Striebich, Sarah

AU - Locher, Christoph

AU - Fedorenko, Olga

AU - Möhle, Robert

AU - Gallinat, Jürgen

AU - Lang, Florian

AU - Lang, Undine E.

PY - 2008/2

Y1 - 2008/2

N2 - Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.

AB - Background: Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. Methods: Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). Results: The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = -0.337, p = 0.0002). Conclusion: Low TSH levels in healthy humans might be linked to an increased risk to develop depression.

KW - Depression

KW - NEO Five-Factor Inventory

KW - Neuroticism

KW - Thyroid function

KW - Thyroid-stimulating hormone

KW - Thyrotropin

UR - http://www.scopus.com/inward/record.url?scp=40349116633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349116633&partnerID=8YFLogxK

U2 - 10.1159/000112954

DO - 10.1159/000112954

M3 - Article

C2 - 18182832

AN - SCOPUS:40349116633

VL - 56

SP - 123

EP - 126

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 2-3

ER -