Three-year experience with fast neutron irradiation using Y-120 cyclotron

B. N. Zyryanov, L. I. Musabayeva, V. A. Lisin, K. A. Lavrenkov, Z. D. Kitsmanyuk, O. D. Shumayeva, M. V. Podoplekin, V. A. Novikov, A. I. Gorbatenko

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Abstract

The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.

Original language	English
Pages (from-to)	1341-1345
Number of pages	5
Journal	Voprosy Onkologii
Volume	35
Issue number	11
Publication status	Published - 1989

ASJC Scopus subject areas

Oncology

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title = "Three-year experience with fast neutron irradiation using Y-120 cyclotron",

abstract = "The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.",

author = "Zyryanov, {B. N.} and Musabayeva, {L. I.} and Lisin, {V. A.} and Lavrenkov, {K. A.} and Kitsmanyuk, {Z. D.} and Shumayeva, {O. D.} and Podoplekin, {M. V.} and Novikov, {V. A.} and Gorbatenko, {A. I.}",

year = "1989",

language = "English",

volume = "35",

pages = "1341--1345",

journal = "Voprosy Onkologii",

issn = "0507-3758",

publisher = "Izdatelstvo Meditsina",

number = "11",

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TY - JOUR

T1 - Three-year experience with fast neutron irradiation using Y-120 cyclotron

AU - Zyryanov, B. N.

AU - Musabayeva, L. I.

AU - Lisin, V. A.

AU - Lavrenkov, K. A.

AU - Kitsmanyuk, Z. D.

AU - Shumayeva, O. D.

AU - Podoplekin, M. V.

AU - Novikov, V. A.

AU - Gorbatenko, A. I.

PY - 1989

Y1 - 1989

N2 - The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.

AB - The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.

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