Three-year experience with fast neutron irradiation using Y-120 cyclotron

B. N. Zyryanov, L. I. Musabayeva, V. A. Lisin, K. A. Lavrenkov, Z. D. Kitsmanyuk, O. D. Shumayeva, M. V. Podoplekin, V. A. Novikov, A. I. Gorbatenko

    Research output: Contribution to journal › Article

    Abstract

    The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.

    Original languageEnglish
    Pages (from-to)1341-1345
    Number of pages5
    JournalVoprosy Onkologii
    Volume35
    Issue number11
    Publication statusPublished - 1989

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    Fast Neutrons
    Cyclotrons
    Neutrons
    Therapeutics
    Head and Neck Neoplasms
    Photons
    Disease-Free Survival
    Neoplasms
    Recurrence

    ASJC Scopus subject areas

    • Oncology

    Cite this

    Zyryanov, B. N., Musabayeva, L. I., Lisin, V. A., Lavrenkov, K. A., Kitsmanyuk, Z. D., Shumayeva, O. D., ... Gorbatenko, A. I. (1989). Three-year experience with fast neutron irradiation using Y-120 cyclotron. Voprosy Onkologii, 35(11), 1341-1345.

    Three-year experience with fast neutron irradiation using Y-120 cyclotron. / Zyryanov, B. N.; Musabayeva, L. I.; Lisin, V. A.; Lavrenkov, K. A.; Kitsmanyuk, Z. D.; Shumayeva, O. D.; Podoplekin, M. V.; Novikov, V. A.; Gorbatenko, A. I.

    In: Voprosy Onkologii, Vol. 35, No. 11, 1989, p. 1341-1345.

    Research output: Contribution to journal › Article

    Zyryanov, BN, Musabayeva, LI, Lisin, VA, Lavrenkov, KA, Kitsmanyuk, ZD, Shumayeva, OD, Podoplekin, MV, Novikov, VA & Gorbatenko, AI 1989, 'Three-year experience with fast neutron irradiation using Y-120 cyclotron', Voprosy Onkologii, vol. 35, no. 11, pp. 1341-1345.
    Zyryanov BN, Musabayeva LI, Lisin VA, Lavrenkov KA, Kitsmanyuk ZD, Shumayeva OD et al. Three-year experience with fast neutron irradiation using Y-120 cyclotron. Voprosy Onkologii. 1989;35(11):1341-1345.
    Zyryanov, B. N. ; Musabayeva, L. I. ; Lisin, V. A. ; Lavrenkov, K. A. ; Kitsmanyuk, Z. D. ; Shumayeva, O. D. ; Podoplekin, M. V. ; Novikov, V. A. ; Gorbatenko, A. I. / Three-year experience with fast neutron irradiation using Y-120 cyclotron. In: Voprosy Onkologii. 1989 ; Vol. 35, No. 11. pp. 1341-1345.
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    AU - Zyryanov, B. N.

    AU - Musabayeva, L. I.

    AU - Lisin, V. A.

    AU - Lavrenkov, K. A.

    AU - Kitsmanyuk, Z. D.

    AU - Shumayeva, O. D.

    AU - Podoplekin, M. V.

    AU - Novikov, V. A.

    AU - Gorbatenko, A. I.

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    AB - The paper discusses the results of treatment of 128 patients with head and neck cancer in whom fast neutrons (Y-120; ~6.2 MeV) were used as a single procedure or in combination with surgery. Tumors of different histomorphologic structure displayed unequal sensitivity to fast neutrons. Mean disease-free survival in patients with complete regression of tumor was 24 months following neutron therapy alone, 18.5 months after combined neutron-photon treatment and 5.5 months only in controls. Relapse rates were 20 and 15% in patients with pre- and postoperative neutron treatment, respectively, as compared to 52% in controls.

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