The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment

A. A. Medvedeva, I. G. Sinilkin, R. V. Zelchan, V. I. Chernov, A. Yu Lyapunov, O. D. Bragina, N. V. Varlamova, V. S. Skuridin, A. P. Dergilev

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Abstract

The purpose of the study was a comparative research of the possibility of using the radiopharmaceuticals 99mTc-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes in the experiment. Measurement of the sizes of 99mTc-Al2O3 and 99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. Pharmacokinetics of 99mTc-Al2O3 and 99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of 99mTc-Al2O3 and 99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. Average dynamic diameter of the sol particle was 52-77 nm for 99mTc-Al2O3 and 16.7-24.5 nm for 99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node - at 1 hour after administration the average uptake of 99mTc-Al2O3 was 8.6% in it and the accumulation of 99mTc-Nanocis was significantly lower - 1,8% (p <0,05). In all study point average uptake of 99mTc-Al2O3 in the lymph node was significantly higher 99mTc-Nanocis accumulation. The results dynamic scintigraphic studies in rats showed that 99mTc-Al2O3 and 99mTc-Nanocis actively accumulated into the lymphatic system. By using 99mTc-Al2O3 inguinal lymph node was determined in 5 minutes after injection and clearly visualize in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the 99mTc-Al2O3 accumulation reaches a plateau in a lymph node (average 10.5%) for 2 hour study and then its accumulation remains practically at the same level, slightly increasing to 12% at 24 hours. In the case of 99mTc-Nanocis inguinal lymph node visualized in all animals for 15 minutes when it was accumulated on the average 1.03% of the administered dose. Plateau of 99mTc-Nanocis accumulation in the lymph node (average 2.05%) occurred at 2 hour of the study and remained almost on the same level (in average 2.3%) to 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the 99mTc-Al2O3 several times actively accumulates in the lymph nodes as compared to imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.

Original languageEnglish
Article number012027
JournalIOP Conference Series: Materials Science and Engineering
Volume135
Issue number1
DOIs
Publication statusPublished - 2 Aug 2016

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Aluminum Oxide
Rats
Aluminum
Oxides
Animals
Radiopharmaceuticals
Pharmacokinetics
Experiments
Sols
Particles (particulate matter)
nanocis
cyhalothrin
Polymethyl Methacrylate

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment. / Medvedeva, A. A.; Sinilkin, I. G.; Zelchan, R. V.; Chernov, V. I.; Lyapunov, A. Yu; Bragina, O. D.; Varlamova, N. V.; Skuridin, V. S.; Dergilev, A. P.

In: IOP Conference Series: Materials Science and Engineering, Vol. 135, No. 1, 012027, 02.08.2016.

Research output: Contribution to journalArticle

Medvedeva, A. A. ; Sinilkin, I. G. ; Zelchan, R. V. ; Chernov, V. I. ; Lyapunov, A. Yu ; Bragina, O. D. ; Varlamova, N. V. ; Skuridin, V. S. ; Dergilev, A. P. / The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment. In: IOP Conference Series: Materials Science and Engineering. 2016 ; Vol. 135, No. 1.
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abstract = "The purpose of the study was a comparative research of the possibility of using the radiopharmaceuticals 99mTc-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes in the experiment. Measurement of the sizes of 99mTc-Al2O3 and 99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. Pharmacokinetics of 99mTc-Al2O3 and 99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of 99mTc-Al2O3 and 99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. Average dynamic diameter of the sol particle was 52-77 nm for 99mTc-Al2O3 and 16.7-24.5 nm for 99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node - at 1 hour after administration the average uptake of 99mTc-Al2O3 was 8.6{\%} in it and the accumulation of 99mTc-Nanocis was significantly lower - 1,8{\%} (p <0,05). In all study point average uptake of 99mTc-Al2O3 in the lymph node was significantly higher 99mTc-Nanocis accumulation. The results dynamic scintigraphic studies in rats showed that 99mTc-Al2O3 and 99mTc-Nanocis actively accumulated into the lymphatic system. By using 99mTc-Al2O3 inguinal lymph node was determined in 5 minutes after injection and clearly visualize in all the animals in the 15th minute, when the accumulation became more than 1{\%} of the administered dose. Further observation indicated that the 99mTc-Al2O3 accumulation reaches a plateau in a lymph node (average 10.5{\%}) for 2 hour study and then its accumulation remains practically at the same level, slightly increasing to 12{\%} at 24 hours. In the case of 99mTc-Nanocis inguinal lymph node visualized in all animals for 15 minutes when it was accumulated on the average 1.03{\%} of the administered dose. Plateau of 99mTc-Nanocis accumulation in the lymph node (average 2.05{\%}) occurred at 2 hour of the study and remained almost on the same level (in average 2.3{\%}) to 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the 99mTc-Al2O3 several times actively accumulates in the lymph nodes as compared to imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.",
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AU - Sinilkin, I. G.

AU - Zelchan, R. V.

AU - Chernov, V. I.

AU - Lyapunov, A. Yu

AU - Bragina, O. D.

AU - Varlamova, N. V.

AU - Skuridin, V. S.

AU - Dergilev, A. P.

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N2 - The purpose of the study was a comparative research of the possibility of using the radiopharmaceuticals 99mTc-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes in the experiment. Measurement of the sizes of 99mTc-Al2O3 and 99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. Pharmacokinetics of 99mTc-Al2O3 and 99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of 99mTc-Al2O3 and 99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. Average dynamic diameter of the sol particle was 52-77 nm for 99mTc-Al2O3 and 16.7-24.5 nm for 99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node - at 1 hour after administration the average uptake of 99mTc-Al2O3 was 8.6% in it and the accumulation of 99mTc-Nanocis was significantly lower - 1,8% (p <0,05). In all study point average uptake of 99mTc-Al2O3 in the lymph node was significantly higher 99mTc-Nanocis accumulation. The results dynamic scintigraphic studies in rats showed that 99mTc-Al2O3 and 99mTc-Nanocis actively accumulated into the lymphatic system. By using 99mTc-Al2O3 inguinal lymph node was determined in 5 minutes after injection and clearly visualize in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the 99mTc-Al2O3 accumulation reaches a plateau in a lymph node (average 10.5%) for 2 hour study and then its accumulation remains practically at the same level, slightly increasing to 12% at 24 hours. In the case of 99mTc-Nanocis inguinal lymph node visualized in all animals for 15 minutes when it was accumulated on the average 1.03% of the administered dose. Plateau of 99mTc-Nanocis accumulation in the lymph node (average 2.05%) occurred at 2 hour of the study and remained almost on the same level (in average 2.3%) to 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the 99mTc-Al2O3 several times actively accumulates in the lymph nodes as compared to imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.

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