The stability of silver nanoparticles in a model of pulmonary surfactant

Bey Fen Leo, Shu Chen, Yoshihiko Kyo, Karla Luise Herpoldt, Nicholas J. Terrill, Iain E. Dunlop, David S. McPhail, Milo S. Shaffer, Stephan Schwander, Andrew Gow, Junfeng Zhang, Kian Fan Chung, Teresa D. Tetley, Alexandra E. Porter, Mary P. Ryan

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The growing use of silver nanoparticles (AgNPs) in consumer products has raised concerns about their potential impact on the environment and human health. Whether AgNPs dissolve and release Ag+ ions, or coarsen to form large aggregates, is critical in determining their potential toxicity. In this work, the stability of AgNPs in dipalmitoylphosphatidylcholine (DPPC), the major component of pulmonary surfactant, was investigated as a function of pH. Spherical, citrate-capped AgNPs with average diameters of 14 ± 1.6 nm (n = 200) were prepared by a chemical bath reduction. The kinetics of Ag + ion release was strongly pH-dependent. After 14 days of incubation in sodium perchlorate (NaClO4) or perchloric acid (HClO4) solutions, the total fraction of AgNPs dissolved varied from ∼10% at pH 3, to ∼2% at pH 5, with negligible dissolution at pH 7. A decrease in pH from 7 to 3 also promoted particle aggregation and coarsening. DPPC (100 mg·L-1) delayed the release of Ag+ ions, but did not significantly alter the total amount of Ag+ released after two weeks. In addition, DPPC improved the dispersion of the AgNPs and inhibited aggregation and coarsening. TEM images revealed that the AgNPs were coated with a DPPC layer serving as a semipermeable layer. Hence, lung lining fluid, particularly DPPC, can modify the aggregation state and kinetics of Ag + ion release of inhaled AgNPs in the lung. These observations have important implications for predicting the potential reactivity of AgNPs in the lung and the environment.

Original languageEnglish
Pages (from-to)11232-11240
Number of pages9
JournalEnvironmental Science and Technology
Volume47
Issue number19
DOIs
Publication statusPublished - 1 Oct 2013
Externally publishedYes

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Pulmonary Surfactants
1,2-Dipalmitoylphosphatidylcholine
Silver
surfactant
silver
Nanoparticles
ion
Ions
Agglomeration
Coarsening
kinetics
perchlorate
Kinetics
Consumer products
transmission electron microscopy
Linings
Citric Acid
incubation
dissolution
sodium

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Leo, B. F., Chen, S., Kyo, Y., Herpoldt, K. L., Terrill, N. J., Dunlop, I. E., ... Ryan, M. P. (2013). The stability of silver nanoparticles in a model of pulmonary surfactant. Environmental Science and Technology, 47(19), 11232-11240. https://doi.org/10.1021/es403377p

The stability of silver nanoparticles in a model of pulmonary surfactant. / Leo, Bey Fen; Chen, Shu; Kyo, Yoshihiko; Herpoldt, Karla Luise; Terrill, Nicholas J.; Dunlop, Iain E.; McPhail, David S.; Shaffer, Milo S.; Schwander, Stephan; Gow, Andrew; Zhang, Junfeng; Chung, Kian Fan; Tetley, Teresa D.; Porter, Alexandra E.; Ryan, Mary P.

In: Environmental Science and Technology, Vol. 47, No. 19, 01.10.2013, p. 11232-11240.

Research output: Contribution to journalArticle

Leo, BF, Chen, S, Kyo, Y, Herpoldt, KL, Terrill, NJ, Dunlop, IE, McPhail, DS, Shaffer, MS, Schwander, S, Gow, A, Zhang, J, Chung, KF, Tetley, TD, Porter, AE & Ryan, MP 2013, 'The stability of silver nanoparticles in a model of pulmonary surfactant', Environmental Science and Technology, vol. 47, no. 19, pp. 11232-11240. https://doi.org/10.1021/es403377p
Leo BF, Chen S, Kyo Y, Herpoldt KL, Terrill NJ, Dunlop IE et al. The stability of silver nanoparticles in a model of pulmonary surfactant. Environmental Science and Technology. 2013 Oct 1;47(19):11232-11240. https://doi.org/10.1021/es403377p
Leo, Bey Fen ; Chen, Shu ; Kyo, Yoshihiko ; Herpoldt, Karla Luise ; Terrill, Nicholas J. ; Dunlop, Iain E. ; McPhail, David S. ; Shaffer, Milo S. ; Schwander, Stephan ; Gow, Andrew ; Zhang, Junfeng ; Chung, Kian Fan ; Tetley, Teresa D. ; Porter, Alexandra E. ; Ryan, Mary P. / The stability of silver nanoparticles in a model of pulmonary surfactant. In: Environmental Science and Technology. 2013 ; Vol. 47, No. 19. pp. 11232-11240.
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