Rol' natrii-protonnogo obmena v reguliatsii élektricheskoi i sokratitel'noi aktivnosti gladkikh myshts.

Translated title of the contribution: The role of sodium-proton exchange in the regulation of the electric and contractile activity of smooth muscles

M. B. Baskakov, I. V. Kovalev, L. V. Kapilevich, M. A. Medvedev

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.

Original languageRussian
Pages (from-to)68-75
Number of pages8
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume86
Issue number1
Publication statusPublished - Jan 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology

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