Abstract
The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.
Translated title of the contribution | The role of sodium-proton exchange in the regulation of the electric and contractile activity of smooth muscles |
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Original language | Russian |
Pages (from-to) | 68-75 |
Number of pages | 8 |
Journal | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk |
Volume | 86 |
Issue number | 1 |
Publication status | Published - Jan 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Physiology