Rol' natrii-protonnogo obmena v reguliatsii élektricheskoi i sokratitel'noi aktivnosti gladkikh myshts.

Translated title of the contribution: The role of sodium-proton exchange in the regulation of the electric and contractile activity of smooth muscles

M. B. Baskakov, I. V. Kovalev, L. V. Kapilevich, M. A. Medvedev

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.

Translated title of the contribution	The role of sodium-proton exchange in the regulation of the electric and contractile activity of smooth muscles
Original language	Russian
Pages (from-to)	68-75
Number of pages	8
Journal	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume	86
Issue number	1
Publication status	Published - Jan 2000
Externally published	Yes

ASJC Scopus subject areas

Physiology

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title = "Rol' natrii-protonnogo obmena v reguliatsii {\'e}lektricheskoi i sokratitel'noi aktivnosti gladkikh myshts.",

abstract = "The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.",

author = "Baskakov, {M. B.} and Kovalev, {I. V.} and Kapilevich, {L. V.} and Medvedev, {M. A.}",

year = "2000",

month = jan,

language = "Русский",

volume = "86",

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journal = "Fiziologicheskii Zhurnal Imeni I.M. Sechenova",

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T1 - Rol' natrii-protonnogo obmena v reguliatsii élektricheskoi i sokratitel'noi aktivnosti gladkikh myshts.

AU - Baskakov, M. B.

AU - Kovalev, I. V.

AU - Kapilevich, L. V.

AU - Medvedev, M. A.

PY - 2000/1

Y1 - 2000/1

N2 - The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.

AB - The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.

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JO - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

JF - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

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