Abstract
The Na+/H+-exchange inhibitor aethylisopropylamyloride was found to enhance the membrane resistance, the AP duration, and the duration of the guinea pig ureter's smooth muscle contraction. Tetraethylammonium and incubation in the Ca-free EG-TA-containing solution eliminated the activating effect of this inhibitor. Gramycidin A shortens the AP plateau. The Na+/H+-exchange mechanism seems to act under normal conditions. Alterations occurring in electrical and contractile activities of smooth muscle under the effect of the Na+/H+-exchange seem to result from the changes in the membrane Ca-dependent potassium conductivity.
| Translated title of the contribution | The role of sodium-proton exchange in the regulation of the electric and contractile activity of smooth muscles |
|---|---|
| Original language | Russian |
| Pages (from-to) | 68-75 |
| Number of pages | 8 |
| Journal | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk |
| Volume | 86 |
| Issue number | 1 |
| Publication status | Published - Jan 2000 |
| Externally published | Yes |
ASJC Scopus subject areas
- Physiology
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Cite this
Baskakov, M. B., Kovalev, I. V., Kapilevich, L. V., & Medvedev, M. A. (2000). Rol' natrii-protonnogo obmena v reguliatsii élektricheskoi i sokratitel'noi aktivnosti gladkikh myshts. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, 86(1), 68-75.