Abstract
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
| Original language | English |
|---|---|
| Pages (from-to) | 598-601 |
| Number of pages | 4 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 166 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 15 Mar 2019 |
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Keywords
- active substance
- heart
- ischemia
- NO synthase
- reperfusion
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart. / Lasukova, T. V.; Zykova, M. V.; Belousov, M. V.; Gorbunov, A. S.; Logvinova, L. A.; Dygai, A. M.
In: Bulletin of Experimental Biology and Medicine, Vol. 166, No. 5, 15.03.2019, p. 598-601.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart
AU - Lasukova, T. V.
AU - Zykova, M. V.
AU - Belousov, M. V.
AU - Gorbunov, A. S.
AU - Logvinova, L. A.
AU - Dygai, A. M.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
AB - The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
KW - active substance
KW - heart
KW - ischemia
KW - NO synthase
KW - reperfusion
UR - http://www.scopus.com/inward/record.url?scp=85063715754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063715754&partnerID=8YFLogxK
U2 - 10.1007/s10517-019-04399-y
DO - 10.1007/s10517-019-04399-y
M3 - Article
VL - 166
SP - 598
EP - 601
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 5
ER -