The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart

Abstract

The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.

Original language	English
Pages (from-to)	598-601
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	166
Issue number	5
DOIs	https://doi.org/10.1007/s10517-019-04399-y
Publication status	Published - 15 Mar 2019

Keywords

active substance
heart
ischemia
NO synthase
reperfusion

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/s10517-019-04399-y

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The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart. / Lasukova, T. V.; Zykova, M. V.; Belousov, M. V.; Gorbunov, A. S.; Logvinova, L. A.; Dygai, A. M.

In: Bulletin of Experimental Biology and Medicine, Vol. 166, No. 5, 15.03.2019, p. 598-601.

Research output: Contribution to journal › Article › peer-review

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abstract = "The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.",

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author = "Lasukova, {T. V.} and Zykova, {M. V.} and Belousov, {M. V.} and Gorbunov, {A. S.} and Logvinova, {L. A.} and Dygai, {A. M.}",

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AU - Lasukova, T. V.

AU - Zykova, M. V.

AU - Belousov, M. V.

AU - Gorbunov, A. S.

AU - Logvinova, L. A.

AU - Dygai, A. M.

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