The role of KATP channels in the cardioprotector action of μ-opioid receptor agonists in acute ischemia and reperfusion of isolated heart

L. N. Maslov, T. V. Lasukova, N. V. Solenkova, Yu B. Lishmanov, S. A. Bogomaz, S. W. Tam, G. J. Gross

Research output: Contribution to journalArticle

Abstract

Preliminary administration of the μ-opioid receptor (μ-OR) agonist DAMGO (0.1 mg/kg) 15 min before heart isolation led to attenuation of the postischemic systolic and diastolic contractility dysfunction in isolated perfused rat heart. In addition, the μ-OR decreased creatine kinase (CK) release from the heart during the postischemic period, which was indicative of an increase in the sarcolemma tolerance to perfusion injury. This protects effects are mediated by KATP channel activation These data show that the μ-OR stimulation in vivo increases, by means of the KATP channel activation, the cardiac tolerance to the ischemia and reperfusion injury in vitro. Pretreatment with μ-OR agonists DAMGO or DALDA in vitro (0.5 mg/liter, 15 min prior to ischemia) exacerbated the postischemic contractility dysfunction of myocardium and did not affect the CK release. It is concluded that the protective effect of μ-OR simulation in vivo is mediated by the activation of these receptors localized outside the heart, probably with an unknown circulating humoral factor.

Original languageEnglish
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume64
Issue number5
Publication statusPublished - 1 Jan 2001

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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