A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca2+-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated with inhibition of Ca permeability and/or Ca-dependent K+ permeability of the plasma membrane.
- Ca ions
- Smooth muscle cells
- Sodium nitroprusside
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)