The role of intracellular Ca²⁺ pool in sodium nitroprusside-induced relaxation of rat aorta smooth muscle cells

I. V. Kovalev, M. B. Baskakov, L. V. Kapilevich, M. A. Medvedev, A. A. Panov, A. G. Popov

Division for Physical Education

Research output: Contribution to journal › Article › peer-review

Abstract

A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca²⁺-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated with inhibition of Ca permeability and/or Ca-dependent K⁺ permeability of the plasma membrane.

Original language	English
Pages (from-to)	160-162
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	127
Issue number	2
DOIs	https://doi.org/10.1007/BF02433102
Publication status	Published - Feb 1999

Keywords

Ca ions
Smooth muscle cells
Sodium nitroprusside

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF02433102

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abstract = "A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca2+-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated with inhibition of Ca permeability and/or Ca-dependent K+ permeability of the plasma membrane.",

keywords = "Ca ions, Smooth muscle cells, Sodium nitroprusside",

author = "Kovalev, {I. V.} and Baskakov, {M. B.} and Kapilevich, {L. V.} and Medvedev, {M. A.} and Panov, {A. A.} and Popov, {A. G.}",

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AU - Kovalev, I. V.

AU - Baskakov, M. B.

AU - Kapilevich, L. V.

AU - Medvedev, M. A.

AU - Panov, A. A.

AU - Popov, A. G.

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AB - A relaxation effect of sodium nitroprusside on smooth muscle cells of rat aorta due to intracellular Ca2+-store refilling is demonstrated using the double sucrose gap technique. It is suggested that sodium nitroprusside-induced repolarization of the smooth muscle cell membrane is associated with inhibition of Ca permeability and/or Ca-dependent K+ permeability of the plasma membrane.

KW - Ca ions

KW - Smooth muscle cells

KW - Sodium nitroprusside

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