Abstract
Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.
Original language | English |
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Pages (from-to) | 20-22 |
Number of pages | 3 |
Journal | Patologicheskaia fiziologiia i èksperimental'naia terapiia. |
Issue number | 4 |
Publication status | Published - Oct 2005 |
ASJC Scopus subject areas
- Medicine(all)