The role of interleukin-5 in manifestation of bronchial hyperreactivity (an experimental study)

A. E. Sazonov, I. I. Ivanchuk, L. V. Kapilevich, E. I. D'iakova, I. S. Popova, A. V. Nosarev, T. N. Zaǐtseva, A. M. Tyryshkin, L. M. Ogorodova

Research output: Contribution to journalArticlepeer-review

Abstract

Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.

Original languageEnglish
Pages (from-to)20-22
Number of pages3
JournalPatologicheskaia fiziologiia i èksperimental'naia terapiia.
Issue number4
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Medicine(all)

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