The role of interleukin-5 in manifestation of bronchial hyperreactivity (an experimental study)

Abstract

Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.

Original language	English
Pages (from-to)	20-22
Number of pages	3
Journal	Patologicheskaia fiziologiia i èksperimental'naia terapiia.
Issue number	4
Publication status	Published - Oct 2005

ASJC Scopus subject areas

Medicine(all)

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The role of interleukin-5 in manifestation of bronchial hyperreactivity (an experimental study). / Sazonov, A. E.; Ivanchuk, I. I.; Kapilevich, L. V.; D'iakova, E. I.; Popova, I. S.; Nosarev, A. V.; Zaǐtseva, T. N.; Tyryshkin, A. M.; Ogorodova, L. M.

In: Patologicheskaia fiziologiia i èksperimental'naia terapiia., No. 4, 10.2005, p. 20-22.

Research output: Contribution to journal › Article › peer-review

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abstract = "Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.",

author = "Sazonov, {A. E.} and Ivanchuk, {I. I.} and Kapilevich, {L. V.} and D'iakova, {E. I.} and Popova, {I. S.} and Nosarev, {A. V.} and Zaǐtseva, {T. N.} and Tyryshkin, {A. M.} and Ogorodova, {L. M.}",

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AU - D'iakova, E. I.

AU - Popova, I. S.

AU - Nosarev, A. V.

AU - Zaǐtseva, T. N.

AU - Tyryshkin, A. M.

AU - Ogorodova, L. M.

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AB - Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.

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