The Role of Humoral Factors in Producing the Cardioprotective Effect of Remote Ischemic Preconditioning

E. S. Prokudina, L. N. Maslov, A. S. Jaggi, D. S. Pismennyi, N. S. Voronkov, E. A. Nesterov

Research output: Contribution to journalArticle

Abstract

The humoral pathway mediating the cardioprotective effect of remote ischemic preconditioning has been demonstrated in various models: ischemia-reperfusion of the fore- and hindlimbs and liver and occlusion-reperfusion of the mesenteric and renal arteries. This review assesses humoral components in the formation and realization of the cardioprotective actions of remote ischemic preconditioning of the heart. Endogenous agonists of opioid receptors, arachidonic acid derivatives (prostanoids), agonists of cannabinoid and vanilloid receptors, calcitonin gene-related peptide, leukotrienes, and microRNA are all regarded as humoral components. Adenosine, which also has a role in mediating the cardioprotective effects of remote ischemic preconditioning, is regarded as a mediator between the humoral factor and cardiomyocytes. Knowledge of the role of humoral factors in mediating cardioprotection may be useful for developing methods and therapeutic agents to increase the resistance of the myocardium to ischemic-reperfusion damage.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalNeuroscience and Behavioral Physiology
Volume49
Issue number3
DOIs
Publication statusPublished - 15 Mar 2019

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Ischemic Preconditioning
Reperfusion
TRPV Cation Channels
Cannabinoid Receptors
Mesenteric Arteries
Forelimb
Calcitonin Gene-Related Peptide
Leukotrienes
Opioid Receptors
Renal Artery
Hindlimb
Reperfusion Injury
MicroRNAs
Cardiac Myocytes
Arachidonic Acid
Adenosine
Prostaglandins
Myocardium
Ischemia
Liver

Keywords

  • cardioprotection
  • humoral factors
  • remote ischemic preconditioning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The Role of Humoral Factors in Producing the Cardioprotective Effect of Remote Ischemic Preconditioning. / Prokudina, E. S.; Maslov, L. N.; Jaggi, A. S.; Pismennyi, D. S.; Voronkov, N. S.; Nesterov, E. A.

In: Neuroscience and Behavioral Physiology, Vol. 49, No. 3, 15.03.2019, p. 289-298.

Research output: Contribution to journalArticle

Prokudina, E. S. ; Maslov, L. N. ; Jaggi, A. S. ; Pismennyi, D. S. ; Voronkov, N. S. ; Nesterov, E. A. / The Role of Humoral Factors in Producing the Cardioprotective Effect of Remote Ischemic Preconditioning. In: Neuroscience and Behavioral Physiology. 2019 ; Vol. 49, No. 3. pp. 289-298.
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