The Role of Endogenous Opioid System in the Regulation of Heart Tolerance to Stress-Induced Damage

Y. B. Lishmanov, S. Y. Tsibul’nikov, N. V. Naryzhnaya, M. V. Korobov, Leonid N. Maslov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In Wistar rats, stress was modeled by 24-h immobilization in a supine posture and stress-induced damage to the heart was assessed by accumulation of 99mTc-pyrophosphate in the myocardium. The intensity of stress reaction was measured by serum levels of cortisol and insulin. Both stressinduced damage to the heart and intensity of stress reaction were examined under control conditions and in rats treated with opioid receptor antagonists naltrexone, methylnaltrexone bromide, MR2266, and ICI174.864. Activation of central μ-opioid receptors with endogenous opioids aggravated stress-induced cardiomyopathy, while stimulation of peripheral μ-opioid receptors produced a cardioprotective effect. The stress-induced damage to the heart was not directly related to up-regulation of cortisol secretion in response to 24-h immobilization. Blockade of the central opioid receptors promoted a decrease in cortisol level in stressed rats.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume163
Issue number1
DOIs
Publication statusAccepted/In press - 3 Jun 2017

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Opioid Receptors
Opioid Analgesics
Hydrocortisone
Rats
Immobilization
Technetium Tc 99m Pyrophosphate
Takotsubo Cardiomyopathy
Naltrexone
Narcotic Antagonists
Posture
Bromides
Wistar Rats
Myocardium
Up-Regulation
Insulin
Chemical activation
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Role of Endogenous Opioid System in the Regulation of Heart Tolerance to Stress-Induced Damage. / Lishmanov, Y. B.; Tsibul’nikov, S. Y.; Naryzhnaya, N. V.; Korobov, M. V.; Maslov, Leonid N.

In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 1, 03.06.2017, p. 1-3.

Research output: Contribution to journalArticle

Lishmanov, Y. B. ; Tsibul’nikov, S. Y. ; Naryzhnaya, N. V. ; Korobov, M. V. ; Maslov, Leonid N. / The Role of Endogenous Opioid System in the Regulation of Heart Tolerance to Stress-Induced Damage. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 1. pp. 1-3.
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