Abstract
Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.
| Original language | English |
|---|---|
| Pages (from-to) | 979-981 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 122 |
| Issue number | 10 |
| Publication status | Published - Oct 1996 |
Keywords
- μ- and δ-opiate receptors
- Adaptation
- Arrhythmias
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Lishmanov, Y. B., Maslov, L. N., Uskina, E. V., & Krylatov, A. V. (1996). The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation. Bulletin of Experimental Biology and Medicine, 122(10), 979-981.