The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation

Abstract

Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	122
Issue number	10
Publication status	Published - Oct 1996

Keywords

μ- and δ-opiate receptors
Adaptation
Arrhythmias

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.",

keywords = "μ- and δ-opiate receptors, Adaptation, Arrhythmias",

author = "Lishmanov, {Yu B.} and Maslov, {L. N.} and Uskina, {E. V.} and Krylatov, {A. V.}",

year = "1996",

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AU - Uskina, E. V.

AU - Krylatov, A. V.

PY - 1996/10

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N2 - Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

AB - Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

KW - μ- and δ-opiate receptors

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KW - Arrhythmias

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The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation

Abstract

Keywords

ASJC Scopus subject areas

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