Abstract
Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.
Original language | English |
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Pages (from-to) | 979-981 |
Number of pages | 3 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 122 |
Issue number | 10 |
Publication status | Published - Oct 1996 |
Keywords
- μ- and δ-opiate receptors
- Adaptation
- Arrhythmias
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)