The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation

Yu B. Lishmanov, L. N. Maslov, E. V. Uskina, A. V. Krylatov

Research output: Contribution to journalArticle


Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

Original languageEnglish
Pages (from-to)979-981
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number10
Publication statusPublished - Oct 1996



  • μ- and δ-opiate receptors
  • Adaptation
  • Arrhythmias

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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