Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.
|Number of pages||3|
|Journal||Bulletin of Experimental Biology and Medicine|
|Publication status||Published - Oct 1996|
- μ- and δ-opiate receptors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)