The promoting effect of pyridine ligands in the Pd-catalysed Heck-Matsuda reaction

Walid Khodja, Alexandre Leclair, Jordi Rull-Barrull, Françoise Zammattio, Ksenia V. Kutonova, Marina E. Trusova, François Xavier Felpin, Mireia Rodriguez-Zubiri

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


An efficient Pd-catalyzed arylation reaction of challenging acyclic olefins, in the presence of an organic ligand, has been disclosed. Commercially available cheap pyridine-based ligands are able to promote good to excellent yields for poorly efficient Heck-Matsuda arylation reactions of several allylic alcohols. A wide range of electronically different arenediazonium salts bearing either electron-releasing or withdrawing groups have been used allowing the synthesis of a range of β-aryl-methoxy-lactols. The catalytic system has been optimised, along with the reaction conditions, in order to achieve remarkable yields in less than 1 h.

Original languageEnglish
Pages (from-to)8855-8862
Number of pages8
JournalNew Journal of Chemistry
Issue number10
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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