Abstract
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
Original language | English |
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Pages (from-to) | 22 |
Number of pages | 1 |
Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
Volume | 59 |
Issue number | 6 |
Publication status | Published - 1996 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)