Abstract
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 22 |
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 59 |
| Issue number | 6 |
| Publication status | Published - 1996 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
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Maslov, L. N., Lishmanov, Y. B., Krylatov, A. V., & Ugdyzhekova, D. S. (1996). The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives. Eksperimental'naya i Klinicheskaya Farmakologiya, 59(6), 22.