The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives

L. N. Maslov, Yu B. Lishmanov, A. V. Krylatov, D. S. Ugdyzhekova

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Abstract

When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.

Original languageEnglish
Pages (from-to)22
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume59
Issue number6
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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