Abstract
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 22 |
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 59 |
| Issue number | 6 |
| Publication status | Published - 1996 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives. / Maslov, L. N.; Lishmanov, Yu B.; Krylatov, A. V.; Ugdyzhekova, D. S.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 59, No. 6, 1996, p. 22.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
AU - Krylatov, A. V.
AU - Ugdyzhekova, D. S.
PY - 1996
Y1 - 1996
N2 - When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
AB - When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
UR - http://www.scopus.com/inward/record.url?scp=1542716792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542716792&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:1542716792
VL - 59
SP - 22
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 6
ER -