When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
|Number of pages||1|
|Journal||Eksperimental'naya i Klinicheskaya Farmakologiya|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)