The molecular aspects of personalized anticancer treatment

N. Cherdyntseva, N. Litviakov, F. Ivanova, E. Denisov, P. Gervas, E. Cherdyntsev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Only 25% of cancer patients, on average, benefit from therapy. Even in the cases of complete clinical response the tumor progression is an event of high level expectation. The main reasons for tumor progression are: intratumor heterogeneity resulted from clonal evolution, drug resistance, and tumor-promoting microenvironment. The reprogramming of microenvironmental stromal-inflammatory components is expected to allow tumor phenotype reversion. So, to find the new effective markers of tumor progression, drug response and targets for therapy, it could be promising to take into account the tumor-microenvironment heterogeneity and tumor clonal evolution.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
EditorsYurii P. Sharkeev, Oleg B. Naimark, Elazar Y. Gutmanas
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414181
DOIs
Publication statusPublished - 2 Aug 2016
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Russian Federation
Duration: 22 Mar 201625 Mar 2016

Publication series

NameAIP Conference Proceedings
Volume1760
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016
CountryRussian Federation
CityTomsk
Period22.3.1625.3.16

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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