The mechanisms of antiarrhythmic effect of agonists of μ-opioid receptors on a model of CaCl2-Induced arrhythmias

Role of the autonomic nervous system

L. N. Maslov, Yu B. Lishmanov, A. V. Krylatov, D. S. Ugdyzhekova

Research output: Contribution to journalArticle

Abstract

It was established that selective ligands of the μ-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2 -induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac μ-opioid receptors.

Original languageEnglish
Pages (from-to)37
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume60
Issue number1
Publication statusPublished - 1997

Fingerprint

Ala(2)-MePhe(4)-Gly(5)-enkephalin
Autonomic Nervous System
Neurology
Opioid Receptors
Cardiac Arrhythmias
Chemical activation
Ligands
tyrosyl-arginyl-phenylalanyl-lysinamide

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{fd4cbcdefe7d45019f5d28f46d9229cc,
title = "The mechanisms of antiarrhythmic effect of agonists of μ-opioid receptors on a model of CaCl2-Induced arrhythmias: Role of the autonomic nervous system",
abstract = "It was established that selective ligands of the μ-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2 -induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac μ-opioid receptors.",
author = "Maslov, {L. N.} and Lishmanov, {Yu B.} and Krylatov, {A. V.} and Ugdyzhekova, {D. S.}",
year = "1997",
language = "English",
volume = "60",
pages = "37",
journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",
issn = "0869-2092",
publisher = "Izdatelstvo Meditsina",
number = "1",

}

TY - JOUR

T1 - The mechanisms of antiarrhythmic effect of agonists of μ-opioid receptors on a model of CaCl2-Induced arrhythmias

T2 - Role of the autonomic nervous system

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Krylatov, A. V.

AU - Ugdyzhekova, D. S.

PY - 1997

Y1 - 1997

N2 - It was established that selective ligands of the μ-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2 -induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac μ-opioid receptors.

AB - It was established that selective ligands of the μ-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2 -induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac μ-opioid receptors.

UR - http://www.scopus.com/inward/record.url?scp=0346543414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346543414&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 37

JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

SN - 0869-2092

IS - 1

ER -