The mechanisms of antiarrhythmic effect of agonists of μ-opioid receptors on a model of CaCl2-Induced arrhythmias: Role of the autonomic nervous system

L. N. Maslov, Yu B. Lishmanov, A. V. Krylatov, D. S. Ugdyzhekova

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Abstract

It was established that selective ligands of the μ-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2 -induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac μ-opioid receptors.

Original languageEnglish
Pages (from-to)37
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume60
Issue number1
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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