The mechanism of the antiarrhythmic effect of opiate receptor's agonist and antagonist

L. N. Maslov, B. Lishmanov Yu., J. I. Szekely

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Enkephalins were injected intravenously at a dose of 0.1 mg/kg 15 minutes or 6 hours before adrenalin or CaCl2 injection. Enkephalins were reported to prevent adrenal ventricular extrasistoles but not to influence CaCl2-induced dysrhythmias. Maximum antiarrhythmic effect of enkephalins was demonstrated 6 hours later after the intravenous injection. Naloxone at a dose of 2 mg/kg and morphine at a dose of 1.5 mg/kg prevent adrenal arrhythmias 15 min and 6 hours later after injection. We believe that peripheral delta opiate receptors activation by enkephalins as well as the blockade of non-identified opiate receptors by naloxone prevent arrhythmias.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume116
Issue number8
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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