The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin

L. N. Maslov, A. V. Krylatov, Yu B. Lishmanov, H. Berger, G. Calo, L. Ma, N. V. Solenkova, D. L. Stakheev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Prophylactic intravenous (i.v.) injections of a selective agonist of ORL1 receptors nociceptin (orphanin FQ) in a dose of 0.4 mg/kg prevented the development of aconitine-induced arrhythmia in rats narcotized with diethyl ether or chloralose. Pretreatment with L-NAME (50 mg/kg) completely abolished this effect of orphanin FQ, while the pretreatment with indomethacin (10 mg/kg) only attenuated the agonist effect, rather than abolished it completely. At the same time, pretreatment with hexamethonium (10 mg/kg) or glibenclamide (3 mg/kg) had no effect on the nociceptin-dependent cardiac tolerance to the arrhythmogenic action of aconitine. Intracerebrovenrticular (i.c.v.) infusion of orphanin FQ (36 μg) also prevented the onset of aconitine-induced arrhythmia, but this effect was completely abolished by hexamethonium. It is concluded that the antiarrhythmic action of nociceptin with respect to aconitine-induced arrhythmia upon i.v. and i.c.v. administration is explained by different mechanisms. In the former case, the effect of orphanin FQ is related to the activation of NO synthase and cyclooxygenase, while the central action involves the vegetative nervous system.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume67
Issue number6
Publication statusPublished - 2004

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Aconitine
Cardiac Arrhythmias
Hexamethonium
Chloralose
Glyburide
Autonomic Nervous System
NG-Nitroarginine Methyl Ester
Neurology
Prostaglandin-Endoperoxide Synthases
Nitric Oxide Synthase
Intravenous Injections
Indomethacin
Intravenous Administration
Ether
nociceptin receptor
nociceptin
Rats
Chemical activation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Maslov, L. N., Krylatov, A. V., Lishmanov, Y. B., Berger, H., Calo, G., Ma, L., ... Stakheev, D. L. (2004). The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin. Eksperimental'naya i Klinicheskaya Farmakologiya, 67(6), 32-35.

The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin. / Maslov, L. N.; Krylatov, A. V.; Lishmanov, Yu B.; Berger, H.; Calo, G.; Ma, L.; Solenkova, N. V.; Stakheev, D. L.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 67, No. 6, 2004, p. 32-35.

Research output: Contribution to journalArticle

Maslov, LN, Krylatov, AV, Lishmanov, YB, Berger, H, Calo, G, Ma, L, Solenkova, NV & Stakheev, DL 2004, 'The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 67, no. 6, pp. 32-35.
Maslov, L. N. ; Krylatov, A. V. ; Lishmanov, Yu B. ; Berger, H. ; Calo, G. ; Ma, L. ; Solenkova, N. V. ; Stakheev, D. L. / The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2004 ; Vol. 67, No. 6. pp. 32-35.
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