The influence of the plasma modification on properties of PCL films as corneal implants

Ekaterina O. Filippova, Nina M. Ivanova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this research is the study the influence of the plasma modification on PCL films properties and the influence PCL films implantation on the morphology of the cornea in vivo experiment. The feedstock for films was obtained by dissolving PCL in the chloroform. Modification of the films was carried out using the low-temperature plasma. Studies were performed on 4 pubescent female Sylvilagus bachmani rabbits. The PCL films were implanted into the cornea of one animal eye. Sampling (animal's eyes) was performed on day 21 after the start of the in vivo experiment for morphology studying. Results showed that the plasma modification increases a roughness (1.5 times) of PCL films, the hydrophilicity of films, reducing the contact angle of the inner side by 9°-10° (12%-14%), and increases the surface energy values mainly due to the polar component to 20.6 ± 0.3 mJ/m2. The implantation of the PLA films contributes to the development of the inflammatory response as a result of the surgery and implantation of the polymer material. The study showed the possibility of the plasma-modified PLA films using as a corneal implant in the future.

Original languageEnglish
Title of host publicationProceedings of the International Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology
EditorsVictor E. Panin, Vasily M. Fomin
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440463
DOIs
Publication statusPublished - 14 Dec 2020
EventInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020 - Tomsk, Russian Federation
Duration: 5 Oct 20209 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2310
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020
CountryRussian Federation
CityTomsk
Period5.10.209.10.20

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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