The influence of implantation of plasma-modified polylactic acid films on the structure of the cornea

Ekaterina O. Filippova, Anna D. Zhuravleva, Evgeniya A. Gorbunova, Nina M. Ivanova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this research is the study the influence of the plasma-modified PLA films implantation on the morphology of the cornea in vivo experiment. Studies were performed on 12 pubescent female Sylvilagus bachmani rabbits. Plasma-modified PLA films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving PLA in the chloroform. Modification of the films was carried out using the low-temperature plasma. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in the course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the plasma-modified PLA films contributes to the development of the mild inflammatory response (mild leukocyte infiltration, newly formed blood vessels, increased twisted stroke of collagen fibers, and presence of strongly acid sulfated GAGs) as a result of the surgery. The study showed the possibility of PLA films using as a corneal implant.

Original languageEnglish
Title of host publicationProceedings of the International Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology
EditorsVictor E. Panin, Vasily M. Fomin
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440463
DOIs
Publication statusPublished - 14 Dec 2020
EventInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020 - Tomsk, Russian Federation
Duration: 5 Oct 20209 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2310
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020
CountryRussian Federation
CityTomsk
Period5.10.209.10.20

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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