Význam stanovení rtg krystalových struktur pro farmacii

Translated title of the contribution: The importance of x-ray crystal structure determinations for pharmacy

Bohumil Kratochvíl, Michal Hušák, Elena I. Korotkova, Alexandr Jegorov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

X-ray structure analysis results have been widely used in the pharmaceutical research, development and control, especially for mapping polymorphism, to determine the chirality of active substances, in the pharmaceutical documentation and patent policy for many years. The greatest progress in X-ray diffraction techniques has been made in improving the quality of the poor material for successful data collection (magnetically oriented microcrystal arrays, serial snapshot crystallography). Prospects of the pharmaceutical application of X-ray crystallography lie in the acceleration of data collection, time-resolved structural studies obtained from the material of pharmaceutical batches without modification, and, in addition to that, in solving structures of semi-solid and amorphous phases and monitoring structural changes in drug formulations.

Original languageCzech
Pages (from-to)40-47
Number of pages8
JournalChemicke Listy
Volume110
Issue number1
Publication statusPublished - 1 Jan 2016

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kratochvíl, B., Hušák, M., Korotkova, E. I., & Jegorov, A. (2016). Význam stanovení rtg krystalových struktur pro farmacii. Chemicke Listy, 110(1), 40-47.