Abstract
The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.
| Original language | English |
|---|---|
| Title of host publication | Physics of Cancer |
| Subtitle of host publication | Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 |
| Editors | Elazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev |
| Publisher | American Institute of Physics Inc. |
| Volume | 1882 |
| ISBN (Electronic) | 9780735415621 |
| DOIs | |
| Publication status | Published - 28 Sep 2017 |
| Event | International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation Duration: 23 May 2017 → 26 May 2017 |
Conference
| Conference | International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 23.5.17 → 26.5.17 |
Fingerprint
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
The foundations of the development of technologies of the synthesis of radiopharmaceuticals. / Larkina, M.; Podrezova, E.; Bragina, O.; Stasyuk, E.; Yusubov, M.; Chernov, V.; Zelchan, R.; Skuridin, V.; Belousov, M.; Deyev, S.
Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. ed. / Elazar Y. Gutmanas; Oleg B. Naimark; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017. 020043.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - The foundations of the development of technologies of the synthesis of radiopharmaceuticals
AU - Larkina, M.
AU - Podrezova, E.
AU - Bragina, O.
AU - Stasyuk, E.
AU - Yusubov, M.
AU - Chernov, V.
AU - Zelchan, R.
AU - Skuridin, V.
AU - Belousov, M.
AU - Deyev, S.
PY - 2017/9/28
Y1 - 2017/9/28
N2 - The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.
AB - The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.
UR - http://www.scopus.com/inward/record.url?scp=85041652033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041652033&partnerID=8YFLogxK
U2 - 10.1063/1.5001622
DO - 10.1063/1.5001622
M3 - Conference contribution
AN - SCOPUS:85041652033
VL - 1882
BT - Physics of Cancer
A2 - Gutmanas, Elazar Y.
A2 - Naimark, Oleg B.
A2 - Sharkeev, Yurii P.
PB - American Institute of Physics Inc.
ER -