The foundations of the development of technologies of the synthesis of radiopharmaceuticals

M. Larkina, E. Podrezova, O. Bragina, E. Stasyuk, M. Yusubov, V. Chernov, R. Zelchan, V. Skuridin, M. Belousov, S. Deyev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
EditorsElazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
PublisherAmerican Institute of Physics Inc.
Volume1882
ISBN (Electronic)9780735415621
DOIs
Publication statusPublished - 28 Sep 2017
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation
Duration: 23 May 201726 May 2017

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
CountryRussian Federation
CityTomsk
Period23.5.1726.5.17

Fingerprint

chelates
carboxylic acids
synthesis
esters
retaining
ketones
purity
room temperature
molecules

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Larkina, M., Podrezova, E., Bragina, O., Stasyuk, E., Yusubov, M., Chernov, V., ... Deyev, S. (2017). The foundations of the development of technologies of the synthesis of radiopharmaceuticals. In E. Y. Gutmanas, O. B. Naimark, & Y. P. Sharkeev (Eds.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Vol. 1882). [020043] American Institute of Physics Inc.. https://doi.org/10.1063/1.5001622

The foundations of the development of technologies of the synthesis of radiopharmaceuticals. / Larkina, M.; Podrezova, E.; Bragina, O.; Stasyuk, E.; Yusubov, M.; Chernov, V.; Zelchan, R.; Skuridin, V.; Belousov, M.; Deyev, S.

Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. ed. / Elazar Y. Gutmanas; Oleg B. Naimark; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017. 020043.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larkina, M, Podrezova, E, Bragina, O, Stasyuk, E, Yusubov, M, Chernov, V, Zelchan, R, Skuridin, V, Belousov, M & Deyev, S 2017, The foundations of the development of technologies of the synthesis of radiopharmaceuticals. in EY Gutmanas, OB Naimark & YP Sharkeev (eds), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. vol. 1882, 020043, American Institute of Physics Inc., International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017, Tomsk, Russian Federation, 23.5.17. https://doi.org/10.1063/1.5001622
Larkina M, Podrezova E, Bragina O, Stasyuk E, Yusubov M, Chernov V et al. The foundations of the development of technologies of the synthesis of radiopharmaceuticals. In Gutmanas EY, Naimark OB, Sharkeev YP, editors, Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. Vol. 1882. American Institute of Physics Inc. 2017. 020043 https://doi.org/10.1063/1.5001622
Larkina, M. ; Podrezova, E. ; Bragina, O. ; Stasyuk, E. ; Yusubov, M. ; Chernov, V. ; Zelchan, R. ; Skuridin, V. ; Belousov, M. ; Deyev, S. / The foundations of the development of technologies of the synthesis of radiopharmaceuticals. Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. editor / Elazar Y. Gutmanas ; Oleg B. Naimark ; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017.
@inproceedings{1fd4dabf130a4839aedfd7fa3c76c21f,
title = "The foundations of the development of technologies of the synthesis of radiopharmaceuticals",
abstract = "The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90{\%} on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91{\%} and found to be stable at room temperature for six hours.",
author = "M. Larkina and E. Podrezova and O. Bragina and E. Stasyuk and M. Yusubov and V. Chernov and R. Zelchan and V. Skuridin and M. Belousov and S. Deyev",
year = "2017",
month = "9",
day = "28",
doi = "10.1063/1.5001622",
language = "English",
volume = "1882",
editor = "Gutmanas, {Elazar Y.} and Naimark, {Oleg B.} and Sharkeev, {Yurii P.}",
booktitle = "Physics of Cancer",
publisher = "American Institute of Physics Inc.",

}

TY - GEN

T1 - The foundations of the development of technologies of the synthesis of radiopharmaceuticals

AU - Larkina, M.

AU - Podrezova, E.

AU - Bragina, O.

AU - Stasyuk, E.

AU - Yusubov, M.

AU - Chernov, V.

AU - Zelchan, R.

AU - Skuridin, V.

AU - Belousov, M.

AU - Deyev, S.

PY - 2017/9/28

Y1 - 2017/9/28

N2 - The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.

AB - The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.

UR - http://www.scopus.com/inward/record.url?scp=85041652033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041652033&partnerID=8YFLogxK

U2 - 10.1063/1.5001622

DO - 10.1063/1.5001622

M3 - Conference contribution

AN - SCOPUS:85041652033

VL - 1882

BT - Physics of Cancer

A2 - Gutmanas, Elazar Y.

A2 - Naimark, Oleg B.

A2 - Sharkeev, Yurii P.

PB - American Institute of Physics Inc.

ER -