Pervyi predstavitel' novogo semeistva éukarioticheskikh faktorov transkriptsii, obnaruzhennyi s pomoshch'iu mezhvidovoi komplementatsii.

Translated title of the contribution: The first member of a novel family of eukaryotic transcription factors detected by the heterospecific complementation

G. V. Shpakovskii, E. N. Lebedenko

Research output: Contribution to journalLetterpeer-review

4 Citations (Scopus)

Abstract

The cDNA of a previously uncharacterized gene fet5 (factor of eukaryotic transcription, clone no. 5) of the fission yeast Schizosaccharomyces pombe was cloned by the heterospecific complementation of a conditional mutant of Saccharomyces cerevisiae defective in the function of the RNA polymerases I-III common subunit ABC10 beta. The gene encodes a new factor of eukaryotic transcription, Fet5, the first member of a superfamily of proteins for which the area of functioning is determined. The Fet5-superfamily consists of three distinct families of proteins highly evolutionarily conserved and widely spread among eukaryotes. Features of the Fet5 amino acid sequence suggest that it belongs to ATP/GTP-binding proteins.

Translated title of the contributionThe first member of a novel family of eukaryotic transcription factors detected by the heterospecific complementation
Original languageRussian
Pages (from-to)234-237
Number of pages4
JournalBioorganicheskaia khimiia
Volume23
Issue number3
Publication statusPublished - Mar 1997

ASJC Scopus subject areas

  • Medicine(all)

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