Abstract
The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.
| Original language | English |
|---|---|
| Title of host publication | Physics of Cancer |
| Subtitle of host publication | Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 |
| Editors | Elazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev |
| Publisher | American Institute of Physics Inc. |
| Volume | 1882 |
| ISBN (Electronic) | 9780735415621 |
| DOIs | |
| Publication status | Published - 28 Sep 2017 |
| Event | International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation Duration: 23 May 2017 → 26 May 2017 |
Conference
| Conference | International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 23.5.17 → 26.5.17 |
Fingerprint
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. / Kuznetsov, P. G.; Tverdokhlebov, S. I.; Goreninskii, S. I.; Bolbasov, E. N.; Popkov, A. V.; Kulbakin, D. E.; Grigoryev, E. G.; Cherdyntseva, N. V.; Choinzonov, E. L.
Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. ed. / Elazar Y. Gutmanas; Oleg B. Naimark; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017. 020040.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing
AU - Kuznetsov, P. G.
AU - Tverdokhlebov, S. I.
AU - Goreninskii, S. I.
AU - Bolbasov, E. N.
AU - Popkov, A. V.
AU - Kulbakin, D. E.
AU - Grigoryev, E. G.
AU - Cherdyntseva, N. V.
AU - Choinzonov, E. L.
PY - 2017/9/28
Y1 - 2017/9/28
N2 - The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.
AB - The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.
UR - http://www.scopus.com/inward/record.url?scp=85041681540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041681540&partnerID=8YFLogxK
U2 - 10.1063/1.5001619
DO - 10.1063/1.5001619
M3 - Conference contribution
AN - SCOPUS:85041681540
VL - 1882
BT - Physics of Cancer
A2 - Gutmanas, Elazar Y.
A2 - Naimark, Oleg B.
A2 - Sharkeev, Yurii P.
PB - American Institute of Physics Inc.
ER -