The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing

P. G. Kuznetsov, S. I. Tverdokhlebov, S. I. Goreninskii, E. N. Bolbasov, A. V. Popkov, D. E. Kulbakin, E. G. Grigoryev, N. V. Cherdyntseva, E. L. Choinzonov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
EditorsElazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
PublisherAmerican Institute of Physics Inc.
Volume1882
ISBN (Electronic)9780735415621
DOIs
Publication statusPublished - 28 Sep 2017
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation
Duration: 23 May 201726 May 2017

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
CountryRussian Federation
CityTomsk
Period23.5.1726.5.17

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ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Kuznetsov, P. G., Tverdokhlebov, S. I., Goreninskii, S. I., Bolbasov, E. N., Popkov, A. V., Kulbakin, D. E., ... Choinzonov, E. L. (2017). The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. In E. Y. Gutmanas, O. B. Naimark, & Y. P. Sharkeev (Eds.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Vol. 1882). [020040] American Institute of Physics Inc.. https://doi.org/10.1063/1.5001619