The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing

Abstract

The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.

Original language	English
Title of host publication	Physics of Cancer
Subtitle of host publication	Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
Editors	Elazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
Publisher	American Institute of Physics Inc.
Volume	1882
ISBN (Electronic)	9780735415621
DOIs	https://doi.org/10.1063/1.5001619
Publication status	Published - 28 Sep 2017
Event	International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation Duration: 23 May 2017 → 26 May 2017

Conference

Conference	International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
Country	Russian Federation
City	Tomsk
Period	23.5.17 → 26.5.17

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1063/1.5001619

Fingerprint Dive into the research topics of 'The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing'. Together they form a unique fingerprint.

Cite this

Kuznetsov, P. G., Tverdokhlebov, S. I., Goreninskii, S. I., Bolbasov, E. N., Popkov, A. V., Kulbakin, D. E., Grigoryev, E. G., Cherdyntseva, N. V., & Choinzonov, E. L. (2017). The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. In E. Y. Gutmanas, O. B. Naimark, & Y. P. Sharkeev (Eds.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Vol. 1882). [020040] American Institute of Physics Inc.. https://doi.org/10.1063/1.5001619

The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. / Kuznetsov, P. G.; Tverdokhlebov, S. I.; Goreninskii, S. I.; Bolbasov, E. N.; Popkov, A. V.; Kulbakin, D. E.; Grigoryev, E. G.; Cherdyntseva, N. V.; Choinzonov, E. L.

Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. ed. / Elazar Y. Gutmanas; Oleg B. Naimark; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017. 020040.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kuznetsov, PG, Tverdokhlebov, SI, Goreninskii, SI, Bolbasov, EN, Popkov, AV, Kulbakin, DE, Grigoryev, EG, Cherdyntseva, NV & Choinzonov, EL 2017, The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. in EY Gutmanas, OB Naimark & YP Sharkeev (eds), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. vol. 1882, 020040, American Institute of Physics Inc., International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017, Tomsk, Russian Federation, 23.5.17. https://doi.org/10.1063/1.5001619

Kuznetsov PG, Tverdokhlebov SI, Goreninskii SI, Bolbasov EN, Popkov AV, Kulbakin DE et al. The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. In Gutmanas EY, Naimark OB, Sharkeev YP, editors, Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. Vol. 1882. American Institute of Physics Inc. 2017. 020040 https://doi.org/10.1063/1.5001619

Kuznetsov, P. G. ; Tverdokhlebov, S. I. ; Goreninskii, S. I. ; Bolbasov, E. N. ; Popkov, A. V. ; Kulbakin, D. E. ; Grigoryev, E. G. ; Cherdyntseva, N. V. ; Choinzonov, E. L. / The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing. Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. editor / Elazar Y. Gutmanas ; Oleg B. Naimark ; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017.

@inproceedings{f9eba7ace3e34a45a79b131e4c8d516c,

title = "The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing",

abstract = "The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.",

author = "Kuznetsov, {P. G.} and Tverdokhlebov, {S. I.} and Goreninskii, {S. I.} and Bolbasov, {E. N.} and Popkov, {A. V.} and Kulbakin, {D. E.} and Grigoryev, {E. G.} and Cherdyntseva, {N. V.} and Choinzonov, {E. L.}",

year = "2017",

month = sep,

day = "28",

doi = "10.1063/1.5001619",

language = "English",

volume = "1882",

editor = "Gutmanas, {Elazar Y.} and Naimark, {Oleg B.} and Sharkeev, {Yurii P.}",

booktitle = "Physics of Cancer",

publisher = "American Institute of Physics Inc.",

note = "International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference date: 23-05-2017 Through 26-05-2017",

}

TY - GEN

T1 - The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing

AU - Kuznetsov, P. G.

AU - Tverdokhlebov, S. I.

AU - Goreninskii, S. I.

AU - Bolbasov, E. N.

AU - Popkov, A. V.

AU - Kulbakin, D. E.

AU - Grigoryev, E. G.

AU - Cherdyntseva, N. V.

AU - Choinzonov, E. L.

PY - 2017/9/28

Y1 - 2017/9/28

N2 - The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.

AB - The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue.

UR - http://www.scopus.com/inward/record.url?scp=85041681540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041681540&partnerID=8YFLogxK

U2 - 10.1063/1.5001619

DO - 10.1063/1.5001619

M3 - Conference contribution

AN - SCOPUS:85041681540

VL - 1882

BT - Physics of Cancer

A2 - Gutmanas, Elazar Y.

A2 - Naimark, Oleg B.

A2 - Sharkeev, Yurii P.

PB - American Institute of Physics Inc.

T2 - International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017

Y2 - 23 May 2017 through 26 May 2017

ER -