The experimental study of '99mTc-ciprofloxacin' for diagnosis of bacterial infection

Yu B. Lishmanov, Svetlana Ivanovna Sazonova, E. G. Sokolovich, K. V. Zavodovskij, V. I. Chernov

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Abstract

Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalMeditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
Volume47
Issue number4
Publication statusPublished - 2002

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Keywords

  • Bacterial infection
  • Diagnosis
  • Pharmacokinetic
  • The Tc-ciprofloxacin

ASJC Scopus subject areas

  • Nuclear Energy and Engineering

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