The experimental study of '<sup>99m</sup>Tc-ciprofloxacin' for diagnosis of bacterial infection

Abstract

Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg ^99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of ^99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of ^99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that ^99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.

Original language	English
Pages (from-to)	49-54
Number of pages	6
Journal	Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
Volume	47
Issue number	4
Publication status	Published - 2002

Keywords

Bacterial infection
Diagnosis
Pharmacokinetic
The Tc-ciprofloxacin

ASJC Scopus subject areas

Nuclear Energy and Engineering

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Cite this

Lishmanov, Y. B., Sazonova, SI., Sokolovich, E. G., Zavodovskij, K. V., & Chernov, V. I. (2002). The experimental study of '^99mTc-ciprofloxacin' for diagnosis of bacterial infection. Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', 47(4), 49-54.

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abstract = "Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.",

keywords = "Bacterial infection, Diagnosis, Pharmacokinetic, The Tc-ciprofloxacin",

author = "Lishmanov, {Yu B.} and Svetlana Ivanovna Sazonova and Sokolovich, {E. G.} and Zavodovskij, {K. V.} and Chernov, {V. I.}",

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AU - Lishmanov, Yu B.

AU - Sazonova, Svetlana Ivanovna

AU - Sokolovich, E. G.

AU - Zavodovskij, K. V.

AU - Chernov, V. I.

PY - 2002

Y1 - 2002

N2 - Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.

AB - Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.

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KW - Diagnosis

KW - Pharmacokinetic

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