Abstract
Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.
| Original language | English |
|---|---|
| Pages (from-to) | 49-54 |
| Number of pages | 6 |
| Journal | Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost' |
| Volume | 47 |
| Issue number | 4 |
| Publication status | Published - 2002 |
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Keywords
- Bacterial infection
- Diagnosis
- Pharmacokinetic
- The Tc-ciprofloxacin
ASJC Scopus subject areas
- Nuclear Energy and Engineering
Cite this
The experimental study of '99mTc-ciprofloxacin' for diagnosis of bacterial infection. / Lishmanov, Yu B.; Sazonova, Svetlana Ivanovna; Sokolovich, E. G.; Zavodovskij, K. V.; Chernov, V. I.
In: Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', Vol. 47, No. 4, 2002, p. 49-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The experimental study of '99mTc-ciprofloxacin' for diagnosis of bacterial infection
AU - Lishmanov, Yu B.
AU - Sazonova, Svetlana Ivanovna
AU - Sokolovich, E. G.
AU - Zavodovskij, K. V.
AU - Chernov, V. I.
PY - 2002
Y1 - 2002
N2 - Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.
AB - Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.
KW - Bacterial infection
KW - Diagnosis
KW - Pharmacokinetic
KW - The Tc-ciprofloxacin
UR - http://www.scopus.com/inward/record.url?scp=0036414036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036414036&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036414036
VL - 47
SP - 49
EP - 54
JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
SN - 0025-8334
IS - 4
ER -