The experimental study of '^99mTc-ciprofloxacin' for diagnosis of bacterial infection

Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg ^99mTc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of ^99mTc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of ^99mTc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that ^99mTc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.