The efficiency of saussurea controversa and fillipendula ulmaria extracts on the background of antibiotic therapy of osteomyelitis in experiment

E. Yu Avdeeva, M. G. Skorokhodova, I. V. Sukhodolo, E. D. Porokhova, G. V. Slizovskii, L. S. Mushtovatova, S. D. Ivanov, Ya E. Reshetov, M. V. Belousov

Research output: Contribution to journalArticle

Abstract

The course application of Saussurea controversa and Fillipendula ulmaria extracts containing a wide range of flavonoglycosides for the treatment of experimental osteomyelitis leads to stimulation of granulopoiesis in 2.8 and 2.2 (p- 0.04) times, respectively, and bone regeneration (density distribution of osteoblasts increased 5 times, p ∗ 0.02) in the affected area in rats. In the bone marrow of rats, there was an increase in the mitotic activity of granulocytes, the number of myeloblasts in 5.6 and 4.2 times (p = 0.02), and the mature forms of granulocytes (2.5 and 1.5 times, p - 0.04) as a result of the antibiotic therapy. Application of the S. controversa extract in the bone marrow of rats with a model osteomyelitis increases the total number of nucleated cells in 2.7 (/> = 0.04) times. There was marked stimulation of regenerative processes (activation of endoosteum and periosteum cells, formation of granulation tissue), and formation of mature bone tissue, which was more pronounced (by 12%, p = 0.02) upon the application of 5. controversa extract in comparison to the meadowsweet extract.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume82
Issue number12
DOIs
Publication statusPublished - 2019

Keywords

  • Experimental osteomyelitis
  • Fillipendula ulmaria (l.) maxim.
  • Histological study
  • Myelogram
  • Rats
  • Saussurea controversa dc

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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