Preliminary stimulation of cardiac δ1-opioid receptors by DPDPE addition at a concentration of 0.1 mg/liter to the perfusion solution decreased the incidence of reperfusion arrhythmias and the reperfusive destruction of cardiac cells. At the same time, the activation of cardiac δ1-opioid receptors resulted in a decrease in myocardial contractility both in the pre-ischemic period and upon restoration of the coronary flow. Pretreatment with naltriondole (a δ-receptor antagonist) or with cyclopiazonic acid (a specific inhibitor of Ca2+ uptake in sarcoplasmic reticulum) completely abolished the antiarrhythmic, cardioprotective, and inotropic effects of DPDPE. It is suggested that the antiarrhythmic, cardioprotective, and inotropic effects of DPDPE is related to the cardiac δ1-opioid receptor activation and Ca2+ transport alteration on the level of sarcoplasmic reticulum.
|Number of pages||6|
|Journal||Eksperimental'naya i Klinicheskaya Farmakologiya|
|Publication status||Published - 2005|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)