The difference in serum proteomes in schizophrenia and bipolar disorder

Liudmila Smirnova, Alexander Seregin, Irina Boksha, Elena Dmitrieva, German Simutkin, Elena Kornetova, Olga Savushkina, Anastasia Letova, Nikolay Bokhan, Svetlana Ivanova, Victor Zgoda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). Results: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 - for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocytes and cell growth. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12) and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p = 0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p = 0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71, 7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001, 4.11] ng/ml). Conclusions: Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders.

Original languageEnglish
Article number535
JournalBMC Genomics
Volume20
DOIs
Publication statusPublished - 11 Jul 2019

Keywords

  • Biomarker
  • Bipolar disorder
  • Mass spectrometry
  • Proteome
  • Schizophrenia
  • Serum

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

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