Sravnenie éffektivnosti terapii atenololom i izosorbida dinitratom u bol'nykh so stenokardiei napriazheniia v sochetanii s arterial'noi gipotenziei.

Translated title of the contribution: The comparison of the efficacy of atenolol and isosorbide dinitrate therapy in chronic hypotension patients with stable angina pectoris

E. M. Idrisova, N. V. Borovkova, T. A. Stepacheva, V. I. Chernov, R. S. Karpov

Research output: Contribution to journalArticlepeer-review

Abstract

Antianginal efficacy of atenolol (A) and isosorbide dinitrate (ID) was compared in a long-term randomized, single-blind, crossover, placebo controlled trial in 71 patients with combined stable angina pectoris and chronic hypotension (Hpts) and in 38 normotensive patients with angina of effort (Npts). Paired bicycle tests showed anti-ischemic activity of drugs: A in 75% and ID in 49% of Hpts, A in 83% and ID in 82% of Npts. Antianginal effect of 25 mg A was observed in 49% of Hpts (vs 6% of Npts; p < 0.01). Secondary resistance to A effect was developed on the treatment week 2-4 in 13% of Hpts (vs 0 in Npts) tolerance to ID effect--on week 1-2 in 71% of Hpts (vs 15% of Npts; p < 0.01) as evidenced by T1-199 exercise myocardial scintigraphy. Hpts needed individual ID therapy with a long-term ID-free period during 8-16 days (vs 3-5 in Npts; p < 0.05) to avoid tolerance. Stable antianginal ID effect manifested with a decrease of myocardial perfusion defect size by 43.1 +/- 1.3% (p < 0.05).

Translated title of the contributionThe comparison of the efficacy of atenolol and isosorbide dinitrate therapy in chronic hypotension patients with stable angina pectoris
Original languageRussian
Pages (from-to)37-40
Number of pages4
JournalKlinicheskaia meditsina
Volume79
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Medicine(all)

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