Sravnitel'naia biokhimicheskaia i morfologicheskaia kharakteristika khondrosarkomy i gigantokletochnoi opukholi kosti.

Translated title of the contribution: The comparative biochemical and morphological characteristics of chondrosarcoma and giant-cell tumor of the bone

O. E. Akbasheva, I. A. Shchepetkin, N. V. Vasil'ev, A. A. Zheravin, I. I. Anisenia, E. V. Buél', I. A. Zhukova

Research output: Contribution to journalArticle

Abstract

Spectrometry has been employed to assess the levels of collagenase, catepsin D, trypsin-like proteinases and their inhibitors as well as bone acid and alkaline phosphatase both in the center and along the periphery of giant cell tumor of bone (GCTB) and chondrosarcoma. The levels of collagenase, trypsin-like proteinases and their inhibitors in the center of chondrosarcoma were much higher while those of alkaline phosphatase--lower than along tumor periphery. The catepsin D and acid phosphatase concentrations of the center and periphery of chondrosarcoma were similar. It was suggested that an extremely low concentration of trypsin-like inhibitors may contribute to degradation of the matrix in tissues adjacent to chondrosarcoma and, consequently, to tumor invasion development.

Translated title of the contributionThe comparative biochemical and morphological characteristics of chondrosarcoma and giant-cell tumor of the bone
Original languageRussian
Pages (from-to)298-301
Number of pages4
JournalVoprosy Onkologii
Volume46
Issue number3
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Akbasheva, O. E., Shchepetkin, I. A., Vasil'ev, N. V., Zheravin, A. A., Anisenia, I. I., Buél', E. V., & Zhukova, I. A. (2000). Sravnitel'naia biokhimicheskaia i morfologicheskaia kharakteristika khondrosarkomy i gigantokletochnoi opukholi kosti. Voprosy Onkologii, 46(3), 298-301.