The change of optical properties of the breast tissues under the influence of pharmacological agents

S. A. Naumov, S. M. Vovk, S. V. Pushcarev, V. A. Volovodenko

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The influence of vasoactive pharmacological agents (VPhA) on the spectral characteristics of the breast tissues in vivo has been studied. The effect of adrenaline and its antagonist dibazole on the character of diffuse reflection spectra of the breast registered during puncture biopsy were investigated. Adrenaline and dibazole were injected both locally, i.e. to the examined breast tissue and subcutaneously to the shoulder. The choice of this or that VPhA was caused by the functional condition of an examinee. It has been shown that the main functional units of the stroma of parenchymatous organs and their tumors responsible for the state of spectral characteristics in vivo are considered to be the vessels. The cancerous tissue has a lesser pronounced response compared to the normal one that is indicative of the functional inferiority of the tumor vessels and it is confirmed by the results of morphological examinations including the ultrastructural level. Thus, using VPhA it is possible to have an influence on characteristics of diffuse reflection spectra of the examined tissues in vivo and make diagnostics more effectively.

    Original languageEnglish
    Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
    EditorsR.R. Anderson, K.E. Bartels, L.S. Bass, C.G. Garrett
    Pages529-535
    Number of pages7
    Volume4244
    DOIs
    Publication statusPublished - 2001
    EventLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI - San Jose,CA, United States
    Duration: 20 Jun 200123 Jun 2001

    Other

    OtherLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI
    CountryUnited States
    CitySan Jose,CA
    Period20.6.0123.6.01

    Keywords

    • Adrenaline
    • Breast cancer
    • Dibazole
    • Doppler
    • Mammary gland
    • Ultrasound
    • Vasoactive

    ASJC Scopus subject areas

    • Electrical and Electronic Engineering
    • Condensed Matter Physics

    Fingerprint Dive into the research topics of 'The change of optical properties of the breast tissues under the influence of pharmacological agents'. Together they form a unique fingerprint.

  • Cite this

    Naumov, S. A., Vovk, S. M., Pushcarev, S. V., & Volovodenko, V. A. (2001). The change of optical properties of the breast tissues under the influence of pharmacological agents. In R. R. Anderson, K. E. Bartels, L. S. Bass, & C. G. Garrett (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4244, pp. 529-535) https://doi.org/10.1117/12.427837