Abstract
The influence of vasoactive pharmacological agents (VPhA) on the spectral characteristics of the breast tissues in vivo has been studied. The effect of adrenaline and its antagonist dibazole on the character of diffuse reflection spectra of the breast registered during puncture biopsy were investigated. Adrenaline and dibazole were injected both locally, i.e. to the examined breast tissue and subcutaneously to the shoulder. The choice of this or that VPhA was caused by the functional condition of an examinee. It has been shown that the main functional units of the stroma of parenchymatous organs and their tumors responsible for the state of spectral characteristics in vivo are considered to be the vessels. The cancerous tissue has a lesser pronounced response compared to the normal one that is indicative of the functional inferiority of the tumor vessels and it is confirmed by the results of morphological examinations including the ultrastructural level. Thus, using VPhA it is possible to have an influence on characteristics of diffuse reflection spectra of the examined tissues in vivo and make diagnostics more effectively.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | R.R. Anderson, K.E. Bartels, L.S. Bass, C.G. Garrett |
| Pages | 529-535 |
| Number of pages | 7 |
| Volume | 4244 |
| DOIs | |
| Publication status | Published - 2001 |
| Event | Laser in Surgery: Advanced Characterization, Therapeutics, and Systems XI - San Jose,CA, United States Duration: 20 Jun 2001 → 23 Jun 2001 |
Other
| Other | Laser in Surgery: Advanced Characterization, Therapeutics, and Systems XI |
|---|---|
| Country | United States |
| City | San Jose,CA |
| Period | 20.6.01 → 23.6.01 |
Fingerprint
Keywords
- Adrenaline
- Breast cancer
- Dibazole
- Doppler
- Mammary gland
- Ultrasound
- Vasoactive
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
The change of optical properties of the breast tissues under the influence of pharmacological agents. / Naumov, S. A.; Vovk, S. M.; Pushcarev, S. V.; Volovodenko, V. A.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / R.R. Anderson; K.E. Bartels; L.S. Bass; C.G. Garrett. Vol. 4244 2001. p. 529-535.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - The change of optical properties of the breast tissues under the influence of pharmacological agents
AU - Naumov, S. A.
AU - Vovk, S. M.
AU - Pushcarev, S. V.
AU - Volovodenko, V. A.
PY - 2001
Y1 - 2001
N2 - The influence of vasoactive pharmacological agents (VPhA) on the spectral characteristics of the breast tissues in vivo has been studied. The effect of adrenaline and its antagonist dibazole on the character of diffuse reflection spectra of the breast registered during puncture biopsy were investigated. Adrenaline and dibazole were injected both locally, i.e. to the examined breast tissue and subcutaneously to the shoulder. The choice of this or that VPhA was caused by the functional condition of an examinee. It has been shown that the main functional units of the stroma of parenchymatous organs and their tumors responsible for the state of spectral characteristics in vivo are considered to be the vessels. The cancerous tissue has a lesser pronounced response compared to the normal one that is indicative of the functional inferiority of the tumor vessels and it is confirmed by the results of morphological examinations including the ultrastructural level. Thus, using VPhA it is possible to have an influence on characteristics of diffuse reflection spectra of the examined tissues in vivo and make diagnostics more effectively.
AB - The influence of vasoactive pharmacological agents (VPhA) on the spectral characteristics of the breast tissues in vivo has been studied. The effect of adrenaline and its antagonist dibazole on the character of diffuse reflection spectra of the breast registered during puncture biopsy were investigated. Adrenaline and dibazole were injected both locally, i.e. to the examined breast tissue and subcutaneously to the shoulder. The choice of this or that VPhA was caused by the functional condition of an examinee. It has been shown that the main functional units of the stroma of parenchymatous organs and their tumors responsible for the state of spectral characteristics in vivo are considered to be the vessels. The cancerous tissue has a lesser pronounced response compared to the normal one that is indicative of the functional inferiority of the tumor vessels and it is confirmed by the results of morphological examinations including the ultrastructural level. Thus, using VPhA it is possible to have an influence on characteristics of diffuse reflection spectra of the examined tissues in vivo and make diagnostics more effectively.
KW - Adrenaline
KW - Breast cancer
KW - Dibazole
KW - Doppler
KW - Mammary gland
KW - Ultrasound
KW - Vasoactive
UR - http://www.scopus.com/inward/record.url?scp=0034936828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034936828&partnerID=8YFLogxK
U2 - 10.1117/12.427837
DO - 10.1117/12.427837
M3 - Conference contribution
AN - SCOPUS:0034936828
VL - 4244
SP - 529
EP - 535
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Anderson, R.R.
A2 - Bartels, K.E.
A2 - Bass, L.S.
A2 - Garrett, C.G.
ER -