The antiviral activity of RNAse Bacillus intermedius in experiments with mice preinfected with street rabies virus

S. V. Gribencha, L. A. Potselueva, I. F. Barinsky, T. G. Balandin, S. M. Deev, I. B. Leshchinskaya

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

RNAse Bacillus intermedius, when administered once and according to 11 repeated experiments, protected the preliminarily infected CBA mice with street rabies virus (protection of 40-67%; p < 0.01-0.001). A reliable protection of Animals was registered only when RNAse was administered intramuscularly at the virus introduction spot; it was not effective, when the bacterial RNAse was injected in the brain, vein, under the skin or in muscles of a non-infected extremity. Neither did it produce any suppressive effect on the vaccinal antirabic immunity.

Original languageEnglish
Pages (from-to)38-41
Number of pages4
JournalVoprosy Virusologii
Volume49
Issue number6
Publication statusPublished - 2004

Keywords

  • Antiviral activity
  • Experimental infection
  • Mice
  • RNase Bacillus intermedius
  • Street rabie virus
  • Vaccinal immunity

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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