The antiarrhythmic effect of enkephalinase inhibitors

Yu B. Lishmanov, L. N. Maslov, E. V. Uskinha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

Original languageEnglish
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume64
Issue number5
Publication statusPublished - 1 Jan 2001

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Neprilysin
Epinephrine
Opiate Alkaloids
Opioid-Related Disorders
Enkephalins
Anti-Arrhythmia Agents
Narcotics
Opioid Receptors
Contrast Media
Chemical activation
racecadotril

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

The antiarrhythmic effect of enkephalinase inhibitors. / Lishmanov, Yu B.; Maslov, L. N.; Uskinha, E. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 64, No. 5, 01.01.2001.

Research output: Contribution to journalArticle

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