The antiarrhythmic effect of enkephalinase inhibitors

Yu B. Lishmanov, L. N. Maslov, E. V. Uskinha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

Original languageEnglish
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume64
Issue number5
Publication statusPublished - 1 Jan 2001

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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