The antiarrhythmic effect of enkephalinase inhibitors

Abstract

The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

Original language	English
Number of pages	1
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	64
Issue number	5
Publication status	Published - 1 Jan 2001

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "The antiarrhythmic effect of enkephalinase inhibitors",

abstract = "The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.",

author = "Lishmanov, {Yu B.} and Maslov, {L. N.} and Uskinha, {E. V.}",

year = "2001",

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N2 - The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

AB - The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

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