Abstract
The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 64 |
| Issue number | 5 |
| Publication status | Published - 1 Jan 2001 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology
Cite this
The antiarrhythmic effect of enkephalinase inhibitors. / Lishmanov, Yu B.; Maslov, L. N.; Uskinha, E. V.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 64, No. 5, 01.01.2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The antiarrhythmic effect of enkephalinase inhibitors
AU - Lishmanov, Yu B.
AU - Maslov, L. N.
AU - Uskinha, E. V.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.
AB - The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.
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UR - http://www.scopus.com/inward/citedby.url?scp=0042195110&partnerID=8YFLogxK
M3 - Article
VL - 64
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 5
ER -