The antiarrhythmic effect of enkephalinase inhibitors

Yu B. Lishmanov, L. N. Maslov, E. V. Uskinha

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.

Original languageEnglish
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number5
Publication statusPublished - 1 Jan 2001

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'The antiarrhythmic effect of enkephalinase inhibitors'. Together they form a unique fingerprint.

Cite this