Abstract
The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine). is related to activation of the δ-opioid receptors by endogenous enkephalins. At the same time, the μ-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 64 |
| Issue number | 5 |
| Publication status | Published - 1 Jan 2001 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology
Cite this
Lishmanov, Y. B., Maslov, L. N., & Uskinha, E. V. (2001). The antiarrhythmic effect of enkephalinase inhibitors. Eksperimental'naya i Klinicheskaya Farmakologiya, 64(5).