The anti-arrhythmic effect of d-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism

Leonid N. Maslov, Yury B. Lishmanov

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We studied antiarrhythmic action of d-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. d-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalInternational Journal of Cardiology
Volume40
Issue number2
DOIs
Publication statusPublished - 1 Jul 1993

Fingerprint

Anti-Arrhythmia Agents
Myocardium
Adrenergic Antagonists
Coronary Occlusion
Somatostatin
Psychological Stress
Myocardial Ischemia
Ala(2)-Arg(6)-enkephalin-leu
Serum

Keywords

  • Arrhythmias
  • Cyclic nucleotides
  • Enkephalins
  • Somatostatin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The anti-arrhythmic effect of d-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism. / Maslov, Leonid N.; Lishmanov, Yury B.

In: International Journal of Cardiology, Vol. 40, No. 2, 01.07.1993, p. 89-94.

Research output: Contribution to journalArticle

@article{b0e23368c383447789c1795d25e915a4,
title = "The anti-arrhythmic effect of d-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism",
abstract = "We studied antiarrhythmic action of d-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. d-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.",
keywords = "Arrhythmias, Cyclic nucleotides, Enkephalins, Somatostatin",
author = "Maslov, {Leonid N.} and Lishmanov, {Yury B.}",
year = "1993",
month = "7",
day = "1",
doi = "10.1016/0167-5273(93)90269-M",
language = "English",
volume = "40",
pages = "89--94",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - The anti-arrhythmic effect of d-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism

AU - Maslov, Leonid N.

AU - Lishmanov, Yury B.

PY - 1993/7/1

Y1 - 1993/7/1

N2 - We studied antiarrhythmic action of d-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. d-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.

AB - We studied antiarrhythmic action of d-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. d-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.

KW - Arrhythmias

KW - Cyclic nucleotides

KW - Enkephalins

KW - Somatostatin

UR - http://www.scopus.com/inward/record.url?scp=0027327285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027327285&partnerID=8YFLogxK

U2 - 10.1016/0167-5273(93)90269-M

DO - 10.1016/0167-5273(93)90269-M

M3 - Article

VL - 40

SP - 89

EP - 94

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -