The σ-receptor antagonist DuP 734 prevents diastolic cardiac dysfunction during reperfusion and oxidative stress

L. N. Maslov, Yu B. Lishmanov, T. Yu Rebrova, P. Giligan, S. W. Tam

Research output: Contribution to journalArticle

Abstract

Intraperitoneal administration of the σ-receptor antagonist DuP 734 (1 mg/kg) 15 min before heart excision produces a decrease in the reperfusion heart contractility and prevented from the reperfusion induced cardiac cell leision upon global ischemia of the isolated perfused rat heart. At the same time, a preliminary treatment with DuP 734 potentiated the reperfusion induced suppression of the cardiac pump function, while affecting neither the cardiac contractility dysfunction nor the cardiac cell injury during the oxidative stress. It is concluded that DuP 734 is not effective in preventing the myocardial stunning. The cardioprotector effect of DuP 734 during reperfusion is not related to inhibition of the free radical cell damage.

Original languageEnglish
Pages (from-to)30
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume63
Issue number5
Publication statusPublished - 2000

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Oxidative stress
Reperfusion
Oxidative Stress
Myocardial Stunning
Myocardial Contraction
Free Radicals
Rats
Ischemia
Cells
Pumps
DuP 734
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The σ-receptor antagonist DuP 734 prevents diastolic cardiac dysfunction during reperfusion and oxidative stress. / Maslov, L. N.; Lishmanov, Yu B.; Rebrova, T. Yu; Giligan, P.; Tam, S. W.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 63, No. 5, 2000, p. 30.

Research output: Contribution to journalArticle

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AU - Tam, S. W.

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