TEMPO-Mediated Oxidative Deformylation of Aldehydes: Applications in the Synthesis of Polyketide Fragments

Andreas Kipke, Kai Uwe Schöning, Mekhman Yusubov, Andreas Kirschning

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3 Citations (Scopus)


A TEMPO-mediated oxidative deformylation of aldehydes is reported that yields the TEMPO adducts, which can be further oxidized to the corresponding ketones. The focus of this work was on the optimization of a synthetic protocol for use in natural product synthesis, specifically for the preparation of chiral backbones with 1,2-oxo functionalization found in polyketide antibiotics. In addition, the oxidative deformylation was combined with the oxidation of the alcohol to the precursor aldehyde in a one-pot protocol.

Original languageEnglish
Pages (from-to)6906-6913
Number of pages8
JournalEuropean Journal of Organic Chemistry
Issue number46
Publication statusPublished - 15 Dec 2017



  • Deformylation
  • Natural products
  • Polyketides
  • Radical reactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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