Temperature-responsive PLLA/PNIPAM nanofibers for switchable release

Roman Elashnikov, Petr Slepička, Silvie Rimpelova, Pavel Ulbrich, Vaclav Švorčík, Oleksiy Lyutakov

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Smart antimicrobial materials with on-demand drug release are highly desired for biomedical applications. Herein, we report about temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) nanospheres doped with crystal violet (CV) and incorporated into the poly-L-lactide (PLLA) nanofibers. The nanofibers were prepared by electrospinning, using different initial polymers ratios. The morphology of the nanofibers and polymers distribution in the nanofibers were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The interaction between PNIPAM and PLLA in the nanofibers was studied by Fourier transform infrared spectroscopy (FTIR) and its effect on the PNIPAM phase transition was also investigated. It was shown that by the changing of the environmental temperature across the lower critical solution temperature (LCST) of PNIPAM, the switchable wettability and controlled CV release can be achieved. The temperature-dependent release kinetics of CV from polymer nanofibers was investigated by ultraviolet-visible spectroscopy (UV–Vis). The temperature-responsive release of antibacterial CV was also tested for triggering of antibacterial activity, which was examined on Staphylococcus epidermidis (S. epidermidis) and Escherichia coli (E. coli). Thus, the proposed material is promising value for controllable drug-release.

Original languageEnglish
Pages (from-to)293-300
Number of pages8
JournalMaterials Science and Engineering C
Volume72
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

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Keywords

  • Antibacterial
  • Electrospinning
  • Nanofibers
  • Polymer blends
  • Responsive release
  • Stimuli-responsive
  • Switchable wettability

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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