TC-99m HMPAO SPECT in the assessment of cerebral complications of coronary artery bypass surgery

V. I. Chernov, Nataliya Yurievna Efimova, I. Yu Efimova, Sh D. Akhmedov, Yu K. Podoksenov, Yu B. Lishmanov

Research Nuclear Reactor Center

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Abstract

The importance of single photon emission computed tomography (SPECT) with ^99mTc-HMPAO for the assessment of cerebral complications of aortal coronary by-passing (ACBP) done under artificial blood circulation (AC) and working heart is investigated. 45 IHD patients were involved in the study, which patients have been surgically treated for myocardial re-vascularization. AC applied surgeries were accompanied by the cerebral flow decrease in the frontal and back lobes of the right hemisphere. Patients treated with AC and Instenon and patients treated without heart stop have not demonstrated confident worsening of the brain perfusion. The cerebral perfusion changes were corresponded by the cognitive status dynamics. SPECT with ^99mTc-HMPAO can be successfully applied to get quantitative evaluation of regional cerebral blood flow in ACBP patients. In such case, ACBP combined with Instenon prophylaxis or surgery at working heart prevent or significantly decrease the risk of cerebral hemodynamic disturbances and cognitive function disorders.

Original language	English
Pages (from-to)	28-34
Number of pages	7
Journal	Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
Volume	48
Issue number	3
Publication status	Published - 2003

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Keywords

Aortal coronary by-passing
Artificial blood flow/ Neurocoegnitive dysfunction
Cerebral perfusion
Single photon emission computed tomography (SPECT)

ASJC Scopus subject areas

Nuclear Energy and Engineering

Cite this

Chernov, V. I., Efimova, NY., Efimova, I. Y., Akhmedov, S. D., Podoksenov, Y. K., & Lishmanov, Y. B. (2003). TC-99m HMPAO SPECT in the assessment of cerebral complications of coronary artery bypass surgery. Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', 48(3), 28-34.

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title = "TC-99m HMPAO SPECT in the assessment of cerebral complications of coronary artery bypass surgery",

abstract = "The importance of single photon emission computed tomography (SPECT) with 99mTc-HMPAO for the assessment of cerebral complications of aortal coronary by-passing (ACBP) done under artificial blood circulation (AC) and working heart is investigated. 45 IHD patients were involved in the study, which patients have been surgically treated for myocardial re-vascularization. AC applied surgeries were accompanied by the cerebral flow decrease in the frontal and back lobes of the right hemisphere. Patients treated with AC and Instenon and patients treated without heart stop have not demonstrated confident worsening of the brain perfusion. The cerebral perfusion changes were corresponded by the cognitive status dynamics. SPECT with 99mTc-HMPAO can be successfully applied to get quantitative evaluation of regional cerebral blood flow in ACBP patients. In such case, ACBP combined with Instenon prophylaxis or surgery at working heart prevent or significantly decrease the risk of cerebral hemodynamic disturbances and cognitive function disorders.",

keywords = "Aortal coronary by-passing, Artificial blood flow/ Neurocoegnitive dysfunction, Cerebral perfusion, Single photon emission computed tomography (SPECT)",

author = "Chernov, {V. I.} and Nataliya Yurievna Efimova and Efimova, {I. Yu} and Akhmedov, {Sh D.} and Podoksenov, {Yu K.} and Lishmanov, {Yu B.}",

year = "2003",

language = "English",

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T1 - TC-99m HMPAO SPECT in the assessment of cerebral complications of coronary artery bypass surgery

AU - Chernov, V. I.

AU - Efimova, Nataliya Yurievna

AU - Efimova, I. Yu

AU - Akhmedov, Sh D.

AU - Podoksenov, Yu K.

AU - Lishmanov, Yu B.

PY - 2003

Y1 - 2003

N2 - The importance of single photon emission computed tomography (SPECT) with 99mTc-HMPAO for the assessment of cerebral complications of aortal coronary by-passing (ACBP) done under artificial blood circulation (AC) and working heart is investigated. 45 IHD patients were involved in the study, which patients have been surgically treated for myocardial re-vascularization. AC applied surgeries were accompanied by the cerebral flow decrease in the frontal and back lobes of the right hemisphere. Patients treated with AC and Instenon and patients treated without heart stop have not demonstrated confident worsening of the brain perfusion. The cerebral perfusion changes were corresponded by the cognitive status dynamics. SPECT with 99mTc-HMPAO can be successfully applied to get quantitative evaluation of regional cerebral blood flow in ACBP patients. In such case, ACBP combined with Instenon prophylaxis or surgery at working heart prevent or significantly decrease the risk of cerebral hemodynamic disturbances and cognitive function disorders.

AB - The importance of single photon emission computed tomography (SPECT) with 99mTc-HMPAO for the assessment of cerebral complications of aortal coronary by-passing (ACBP) done under artificial blood circulation (AC) and working heart is investigated. 45 IHD patients were involved in the study, which patients have been surgically treated for myocardial re-vascularization. AC applied surgeries were accompanied by the cerebral flow decrease in the frontal and back lobes of the right hemisphere. Patients treated with AC and Instenon and patients treated without heart stop have not demonstrated confident worsening of the brain perfusion. The cerebral perfusion changes were corresponded by the cognitive status dynamics. SPECT with 99mTc-HMPAO can be successfully applied to get quantitative evaluation of regional cerebral blood flow in ACBP patients. In such case, ACBP combined with Instenon prophylaxis or surgery at working heart prevent or significantly decrease the risk of cerebral hemodynamic disturbances and cognitive function disorders.

KW - Aortal coronary by-passing

KW - Artificial blood flow/ Neurocoegnitive dysfunction

KW - Cerebral perfusion

KW - Single photon emission computed tomography (SPECT)

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