Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies

S. M. Deyev, E. N. Lebedenko

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this review, the authors' works published within the past 5 years devoted to the development of bifunctional hybrid nanostructures based on the targeting polypeptides and nanoparticles of various origin (quantum dots, nanogold, nanodiamonds, upconversion nanoparticles, magnetic and polymer nanoparticles) as modules that ensure visualization and various damaging effects on cancer cells are surveyed and the prospects of their application in theranostics and precision medicine have been contemplated.

Original languageEnglish
Pages (from-to)788-803
Number of pages16
JournalMolecular Biology
Volume51
Issue number6
DOIs
Publication statusPublished - 1 Nov 2017
Externally publishedYes

Keywords

  • Biocomputing
  • DARPins
  • exotoxin A
  • HER2
  • imaging
  • nanogold
  • NIR
  • photodynamic and photothermal therapies
  • protein photosensitizers
  • riboflavin
  • scFv
  • tumor xenografts
  • upconverting nanophosphores

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

Fingerprint Dive into the research topics of 'Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies'. Together they form a unique fingerprint.

Cite this