Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies

Abstract

In this review, the authors' works published within the past 5 years devoted to the development of bifunctional hybrid nanostructures based on the targeting polypeptides and nanoparticles of various origin (quantum dots, nanogold, nanodiamonds, upconversion nanoparticles, magnetic and polymer nanoparticles) as modules that ensure visualization and various damaging effects on cancer cells are surveyed and the prospects of their application in theranostics and precision medicine have been contemplated.

Original language	English
Pages (from-to)	788-803
Number of pages	16
Journal	Molecular Biology
Volume	51
Issue number	6
DOIs	https://doi.org/10.1134/S002689331706005X
Publication status	Published - 1 Nov 2017
Externally published	Yes

Keywords

Biocomputing
DARPins
exotoxin A
HER2
imaging
nanogold
NIR
photodynamic and photothermal therapies
protein photosensitizers
riboflavin
scFv
tumor xenografts
upconverting nanophosphores

ASJC Scopus subject areas

Biophysics
Structural Biology

Access to Document

10.1134/S002689331706005X

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Cite this

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title = "Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies",

abstract = "In this review, the authors' works published within the past 5 years devoted to the development of bifunctional hybrid nanostructures based on the targeting polypeptides and nanoparticles of various origin (quantum dots, nanogold, nanodiamonds, upconversion nanoparticles, magnetic and polymer nanoparticles) as modules that ensure visualization and various damaging effects on cancer cells are surveyed and the prospects of their application in theranostics and precision medicine have been contemplated.",

keywords = "Biocomputing, DARPins, exotoxin A, HER2, imaging, nanogold, NIR, photodynamic and photothermal therapies, protein photosensitizers, riboflavin, scFv, tumor xenografts, upconverting nanophosphores",

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KW - imaging

KW - nanogold

KW - NIR

KW - photodynamic and photothermal therapies

KW - protein photosensitizers

KW - riboflavin

KW - scFv

KW - tumor xenografts

KW - upconverting nanophosphores

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