Abstract
Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.
| Original language | English |
|---|---|
| Pages (from-to) | 475-481 |
| Number of pages | 7 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 30 Apr 2009 |
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Keywords
- DRD3
- Extrapyramidal syndromes
- HTR2A
- HTR2C
- Pharmacogenetics
- Tardive dyskinesia
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. / Al Hadithy, A. F Y; Ivanova, S. A.; Pechlivanoglou, P.; Semke, A.; Fedorenko, O.; Kornetova, E.; Ryadovaya, L.; Brouwers, J. R B J; Wilffert, B.; Bruggeman, R.; Loonen, A. J M.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 3, 30.04.2009, p. 475-481.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia
AU - Al Hadithy, A. F Y
AU - Ivanova, S. A.
AU - Pechlivanoglou, P.
AU - Semke, A.
AU - Fedorenko, O.
AU - Kornetova, E.
AU - Ryadovaya, L.
AU - Brouwers, J. R B J
AU - Wilffert, B.
AU - Bruggeman, R.
AU - Loonen, A. J M
PY - 2009/4/30
Y1 - 2009/4/30
N2 - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.
AB - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.
KW - DRD3
KW - Extrapyramidal syndromes
KW - HTR2A
KW - HTR2C
KW - Pharmacogenetics
KW - Tardive dyskinesia
UR - http://www.scopus.com/inward/record.url?scp=63149117860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63149117860&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2009.01.010
DO - 10.1016/j.pnpbp.2009.01.010
M3 - Article
VL - 33
SP - 475
EP - 481
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 3
ER -