Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

A. F Y Al Hadithy, S. A. Ivanova, P. Pechlivanoglou, A. Semke, O. Fedorenko, E. Kornetova, L. Ryadovaya, J. R B J Brouwers, B. Wilffert, R. Bruggeman, A. J M Loonen

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number3
DOIs
Publication statusPublished - 30 Apr 2009

Fingerprint

Siberia
Dyskinesias
Psychiatry
Inpatients
Extremities
Pharmacogenetics
Alleles
Receptor, Serotonin, 5-HT2C
Genes
Receptor, Serotonin, 5-HT2A
Dopamine
Logistic Models
Regression Analysis
Population
Tardive Dyskinesia

Keywords

  • DRD3
  • Extrapyramidal syndromes
  • HTR2A
  • HTR2C
  • Pharmacogenetics
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. / Al Hadithy, A. F Y; Ivanova, S. A.; Pechlivanoglou, P.; Semke, A.; Fedorenko, O.; Kornetova, E.; Ryadovaya, L.; Brouwers, J. R B J; Wilffert, B.; Bruggeman, R.; Loonen, A. J M.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 3, 30.04.2009, p. 475-481.

Research output: Contribution to journalArticle

Al Hadithy, AFY, Ivanova, SA, Pechlivanoglou, P, Semke, A, Fedorenko, O, Kornetova, E, Ryadovaya, L, Brouwers, JRBJ, Wilffert, B, Bruggeman, R & Loonen, AJM 2009, 'Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 3, pp. 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010
Al Hadithy, A. F Y ; Ivanova, S. A. ; Pechlivanoglou, P. ; Semke, A. ; Fedorenko, O. ; Kornetova, E. ; Ryadovaya, L. ; Brouwers, J. R B J ; Wilffert, B. ; Bruggeman, R. ; Loonen, A. J M. / Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009 ; Vol. 33, No. 3. pp. 475-481.
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AU - Al Hadithy, A. F Y

AU - Ivanova, S. A.

AU - Pechlivanoglou, P.

AU - Semke, A.

AU - Fedorenko, O.

AU - Kornetova, E.

AU - Ryadovaya, L.

AU - Brouwers, J. R B J

AU - Wilffert, B.

AU - Bruggeman, R.

AU - Loonen, A. J M

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N2 - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

AB - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

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