Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

Abstract

Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.pnpbp.2009.01.010
Publication status	Published - 30 Apr 2009

Keywords

DRD3
Extrapyramidal syndromes
HTR2A
HTR2C
Pharmacogenetics
Tardive dyskinesia

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

Access to Document

10.1016/j.pnpbp.2009.01.010

Fingerprint Dive into the research topics of 'Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia'. Together they form a unique fingerprint.

Cite this

Al Hadithy, A. F. Y., Ivanova, S. A., Pechlivanoglou, P., Semke, A., Fedorenko, O., Kornetova, E., Ryadovaya, L., Brouwers, J. R. B. J., Wilffert, B., Bruggeman, R., & Loonen, A. J. M. (2009). Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(3), 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. / Al Hadithy, A. F Y; Ivanova, S. A.; Pechlivanoglou, P.; Semke, A.; Fedorenko, O.; Kornetova, E.; Ryadovaya, L.; Brouwers, J. R B J; Wilffert, B.; Bruggeman, R.; Loonen, A. J M.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 3, 30.04.2009, p. 475-481.

Research output: Contribution to journal › Article

Al Hadithy, AFY, Ivanova, SA, Pechlivanoglou, P, Semke, A, Fedorenko, O, Kornetova, E, Ryadovaya, L, Brouwers, JRBJ, Wilffert, B, Bruggeman, R & Loonen, AJM 2009, 'Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 3, pp. 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010

Al Hadithy, A. F Y ; Ivanova, S. A. ; Pechlivanoglou, P. ; Semke, A. ; Fedorenko, O. ; Kornetova, E. ; Ryadovaya, L. ; Brouwers, J. R B J ; Wilffert, B. ; Bruggeman, R. ; Loonen, A. J M. / Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009 ; Vol. 33, No. 3. pp. 475-481.

@article{c6fb6170a469445db9c14c0fc731240a,

title = "Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia",

abstract = "Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.",

keywords = "DRD3, Extrapyramidal syndromes, HTR2A, HTR2C, Pharmacogenetics, Tardive dyskinesia",

author = "{Al Hadithy}, {A. F Y} and Ivanova, {S. A.} and P. Pechlivanoglou and A. Semke and O. Fedorenko and E. Kornetova and L. Ryadovaya and Brouwers, {J. R B J} and B. Wilffert and R. Bruggeman and Loonen, {A. J M}",

year = "2009",

month = apr,

day = "30",

doi = "10.1016/j.pnpbp.2009.01.010",

language = "English",

volume = "33",

pages = "475--481",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

AU - Al Hadithy, A. F Y

AU - Ivanova, S. A.

AU - Pechlivanoglou, P.

AU - Semke, A.

AU - Fedorenko, O.

AU - Kornetova, E.

AU - Ryadovaya, L.

AU - Brouwers, J. R B J

AU - Wilffert, B.

AU - Bruggeman, R.

AU - Loonen, A. J M

PY - 2009/4/30

Y1 - 2009/4/30

N2 - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

AB - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

KW - DRD3

KW - Extrapyramidal syndromes

KW - HTR2A

KW - HTR2C

KW - Pharmacogenetics

KW - Tardive dyskinesia

UR - http://www.scopus.com/inward/record.url?scp=63149117860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63149117860&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2009.01.010

DO - 10.1016/j.pnpbp.2009.01.010

M3 - Article

C2 - 19439249

AN - SCOPUS:63149117860

VL - 33

SP - 475

EP - 481

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 3

ER -