Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

A. F Y Al Hadithy, S. A. Ivanova, P. Pechlivanoglou, A. Semke, O. Fedorenko, E. Kornetova, L. Ryadovaya, J. R B J Brouwers, B. Wilffert, R. Bruggeman, A. J M Loonen

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46 Citations (Scopus)

Abstract

Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23Ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia. Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use). Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23Ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt. Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number3
DOIs
Publication statusPublished - 30 Apr 2009

Keywords

  • DRD3
  • Extrapyramidal syndromes
  • HTR2A
  • HTR2C
  • Pharmacogenetics
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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    Al Hadithy, A. F. Y., Ivanova, S. A., Pechlivanoglou, P., Semke, A., Fedorenko, O., Kornetova, E., Ryadovaya, L., Brouwers, J. R. B. J., Wilffert, B., Bruggeman, R., & Loonen, A. J. M. (2009). Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(3), 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010