Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

O. A. Nurkenov, M. K. Ibraev, I. A. Schepetkin, A. I. Khlebnikov, T. M. Seilkhanov, A. E. Arinova, M. B. Isabaeva

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Abstract

Functionally substituted chalcones, pyrazolines, and flavonones have been synthesized. Their structure has been studied by means of 1H and 13C NMR spectroscopy, including COSY and HMQC experiments. Anti-inflammatory activity of the synthesized chalcones, pyrazolines, and flavonones has been evaluated.

Original languageEnglish
Pages (from-to)1360-1367
Number of pages8
JournalRussian Journal of General Chemistry
Volume89
Issue number7
DOIs
Publication statusPublished - 1 Jul 2019

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Keywords

  • chalcone
  • cytokine
  • flavonone
  • pyrazoline
  • substituted aromatic aldehydes
  • transcription factor NF-κB

ASJC Scopus subject areas

  • Chemistry(all)

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