Synthesis of unsymmetrical hetaryl-1,2-diketones

Mehman S. Yusubov, Galina A. Zholobova, Sergey F. Vasilevsky, Eugene V. Tretyakov, David W. Knight

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl₂-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

Original language	English
Pages (from-to)	1607-1610
Number of pages	4
Journal	Tetrahedron
Volume	58
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(02)00025-X
Publication status	Published - 18 Feb 2002

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Keywords

1,2-diketones
Alkynes
Oxidation with PdCl-DMSO

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Yusubov, M. S., Zholobova, G. A., Vasilevsky, S. F., Tretyakov, E. V., & Knight, D. W. (2002). Synthesis of unsymmetrical hetaryl-1,2-diketones. Tetrahedron, 58(8), 1607-1610. https://doi.org/10.1016/S0040-4020(02)00025-X

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AU - Yusubov, Mehman S.

AU - Zholobova, Galina A.

AU - Vasilevsky, Sergey F.

AU - Tretyakov, Eugene V.

AU - Knight, David W.

PY - 2002/2/18

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N2 - Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl2-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

AB - Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl2-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

KW - 1,2-diketones

KW - Alkynes

KW - Oxidation with PdCl-DMSO

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Access to Document

10.1016/S0040-4020(02)00025-X