Synthesis of unsymmetrical hetaryl-1,2-diketones

Mehman S. Yusubov, Galina A. Zholobova, Sergey F. Vasilevsky, Eugene V. Tretyakov, David W. Knight

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl₂-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

Original language	English
Pages (from-to)	1607-1610
Number of pages	4
Journal	Tetrahedron
Volume	58
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(02)00025-X
Publication status	Published - 18 Feb 2002

Keywords

1,2-diketones
Alkynes
Oxidation with PdCl-DMSO

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4020(02)00025-X

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title = "Synthesis of unsymmetrical hetaryl-1,2-diketones",

abstract = "Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl2-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.",

keywords = "1,2-diketones, Alkynes, Oxidation with PdCl-DMSO",

author = "Yusubov, {Mehman S.} and Zholobova, {Galina A.} and Vasilevsky, {Sergey F.} and Tretyakov, {Eugene V.} and Knight, {David W.}",

year = "2002",

month = feb,

day = "18",

doi = "10.1016/S0040-4020(02)00025-X",

language = "English",

volume = "58",

pages = "1607--1610",

journal = "Tetrahedron",

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T1 - Synthesis of unsymmetrical hetaryl-1,2-diketones

AU - Yusubov, Mehman S.

AU - Zholobova, Galina A.

AU - Vasilevsky, Sergey F.

AU - Tretyakov, Eugene V.

AU - Knight, David W.

PY - 2002/2/18

Y1 - 2002/2/18

N2 - Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl2-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

AB - Oxidation of the triple bond in 4-alkynylpyrazoles 2a-e and acetylenic derivatives of the crown-ethers 7a,b with PdCl2-DMSO has been carried out to give unsymmetrical hetaryl-1,2-diketones 3a-e; 8a,b. Attempts to oxidize the triple bond in 5-alkynylpyrazole 6 and alkynylpyridines 5a,b and 9 failed.

KW - 1,2-diketones

KW - Alkynes

KW - Oxidation with PdCl-DMSO

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U2 - 10.1016/S0040-4020(02)00025-X

DO - 10.1016/S0040-4020(02)00025-X

M3 - Article

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VL - 58

SP - 1607

EP - 1610

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 8