Abstract
A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.
| Original language | English |
|---|---|
| Pages (from-to) | 70-76 |
| Number of pages | 7 |
| Journal | Russian Journal of Bioorganic Chemistry |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
| Externally published | Yes |
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Keywords
- anti-inflammatory activity
- combretastatin A-4
- vasoactive properties
- α-acetylenic ketones
- β-vinylamines
ASJC Scopus subject areas
- Organic Chemistry
- Biochemistry
Cite this
Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity. / Davydova, M. P.; Sorokina, I. V.; Tolstikova, T. G.; Mamatyuk, V. I.; Fadeev, D. S.; Vasilevsky, S. F.
In: Russian Journal of Bioorganic Chemistry, Vol. 41, No. 1, 01.01.2015, p. 70-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity
AU - Davydova, M. P.
AU - Sorokina, I. V.
AU - Tolstikova, T. G.
AU - Mamatyuk, V. I.
AU - Fadeev, D. S.
AU - Vasilevsky, S. F.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.
AB - A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.
KW - anti-inflammatory activity
KW - combretastatin A-4
KW - vasoactive properties
KW - α-acetylenic ketones
KW - β-vinylamines
UR - http://www.scopus.com/inward/record.url?scp=84921653565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921653565&partnerID=8YFLogxK
U2 - 10.1134/S1068162015010033
DO - 10.1134/S1068162015010033
M3 - Article
VL - 41
SP - 70
EP - 76
JO - Russian Journal of Bioorganic Chemistry
JF - Russian Journal of Bioorganic Chemistry
SN - 1068-1620
IS - 1
ER -