Abstract
A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.
| Original language | English |
|---|---|
| Pages (from-to) | 70-76 |
| Number of pages | 7 |
| Journal | Russian Journal of Bioorganic Chemistry |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
| Externally published | Yes |
Keywords
- anti-inflammatory activity
- combretastatin A-4
- vasoactive properties
- α-acetylenic ketones
- β-vinylamines
ASJC Scopus subject areas
- Organic Chemistry
- Biochemistry
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Cite this
Davydova, M. P., Sorokina, I. V., Tolstikova, T. G., Mamatyuk, V. I., Fadeev, D. S., & Vasilevsky, S. F. (2015). Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity. Russian Journal of Bioorganic Chemistry, 41(1), 70-76. https://doi.org/10.1134/S1068162015010033