Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity

M. P. Davydova, I. V. Sorokina, T. G. Tolstikova, V. I. Mamatyuk, D. S. Fadeev, S. F. Vasilevsky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalRussian Journal of Bioorganic Chemistry
Volume41
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Fingerprint

Amines
Anti-Inflammatory Agents
Concanavalin A
Ketones
Histamine
Inflammation
fosbretabulin
piperidine
morpholine
pyrrolidine

Keywords

  • anti-inflammatory activity
  • combretastatin A-4
  • vasoactive properties
  • α-acetylenic ketones
  • β-vinylamines

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

Cite this

Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity. / Davydova, M. P.; Sorokina, I. V.; Tolstikova, T. G.; Mamatyuk, V. I.; Fadeev, D. S.; Vasilevsky, S. F.

In: Russian Journal of Bioorganic Chemistry, Vol. 41, No. 1, 01.01.2015, p. 70-76.

Research output: Contribution to journalArticle

Davydova, M. P. ; Sorokina, I. V. ; Tolstikova, T. G. ; Mamatyuk, V. I. ; Fadeev, D. S. ; Vasilevsky, S. F. / Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity. In: Russian Journal of Bioorganic Chemistry. 2015 ; Vol. 41, No. 1. pp. 70-76.
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