Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity

M. P. Davydova, I. V. Sorokina, T. G. Tolstikova, V. I. Mamatyuk, D. S. Fadeev, S. F. Vasilevsky

Research output: Contribution to journal › Article

Abstract

New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalBioorganicheskaia khimiia
Volume41
Issue number1
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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Amines
Anti-Inflammatory Agents
Ketones
fosbretabulin
piperidine
morpholine
pyrrolidine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Davydova, M. P., Sorokina, I. V., Tolstikova, T. G., Mamatyuk, V. I., Fadeev, D. S., & Vasilevsky, S. F. (2015). Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. Bioorganicheskaia khimiia, 41(1), 82-89.

Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. / Davydova, M. P.; Sorokina, I. V.; Tolstikova, T. G.; Mamatyuk, V. I.; Fadeev, D. S.; Vasilevsky, S. F.

In: Bioorganicheskaia khimiia, Vol. 41, No. 1, 01.01.2015, p. 82-89.

Research output: Contribution to journal › Article

Davydova, MP, Sorokina, IV, Tolstikova, TG, Mamatyuk, VI, Fadeev, DS & Vasilevsky, SF 2015, 'Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity', Bioorganicheskaia khimiia, vol. 41, no. 1, pp. 82-89.
Davydova MP, Sorokina IV, Tolstikova TG, Mamatyuk VI, Fadeev DS, Vasilevsky SF. Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. Bioorganicheskaia khimiia. 2015 Jan 1;41(1):82-89.
Davydova, M. P. ; Sorokina, I. V. ; Tolstikova, T. G. ; Mamatyuk, V. I. ; Fadeev, D. S. ; Vasilevsky, S. F. / Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. In: Bioorganicheskaia khimiia. 2015 ; Vol. 41, No. 1. pp. 82-89.
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