Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity

M. P. Davydova, I. V. Sorokina, T. G. Tolstikova, V. I. Mamatyuk, D. S. Fadeev, S. F. Vasilevsky

Research output: Contribution to journal › Article › peer-review

Abstract

New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.

Original language	English
Pages (from-to)	82-89
Number of pages	8
Journal	Bioorganicheskaia khimiia
Volume	41
Issue number	1
Publication status	Published - 1 Jan 2015
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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abstract = "New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.",

author = "Davydova, {M. P.} and Sorokina, {I. V.} and Tolstikova, {T. G.} and Mamatyuk, {V. I.} and Fadeev, {D. S.} and Vasilevsky, {S. F.}",

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AU - Sorokina, I. V.

AU - Tolstikova, T. G.

AU - Mamatyuk, V. I.

AU - Fadeev, D. S.

AU - Vasilevsky, S. F.

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AB - New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.

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