Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity

M. P. Davydova, I. V. Sorokina, T. G. Tolstikova, V. I. Mamatyuk, D. S. Fadeev, S. F. Vasilevsky

Research output: Contribution to journalArticle

Abstract

New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalBioorganicheskaia khimiia
Volume41
Issue number1
Publication statusPublished - 1 Jan 2015
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Davydova, M. P., Sorokina, I. V., Tolstikova, T. G., Mamatyuk, V. I., Fadeev, D. S., & Vasilevsky, S. F. (2015). Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. Bioorganicheskaia khimiia, 41(1), 82-89.