Abstract
New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.
Original language | English |
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Pages (from-to) | 82-89 |
Number of pages | 8 |
Journal | Bioorganicheskaia khimiia |
Volume | 41 |
Issue number | 1 |
Publication status | Published - 1 Jan 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)