Abstract
New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.
| Original language | English |
|---|---|
| Pages (from-to) | 82-89 |
| Number of pages | 8 |
| Journal | Bioorganicheskaia khimiia |
| Volume | 41 |
| Issue number | 1 |
| Publication status | Published - 1 Jan 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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Davydova, M. P., Sorokina, I. V., Tolstikova, T. G., Mamatyuk, V. I., Fadeev, D. S., & Vasilevsky, S. F. (2015). Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity. Bioorganicheskaia khimiia, 41(1), 82-89.