Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation

S. V. German, O. A. Inozemtseva, N. A. Navolokin, E. E. Pudovkina, V. V. Zuev, E. K. Volkova, A. B. Bucharskaya, S. N. Pleskova, G. N. Maslyakova, D. A. Gorin

Research output: Contribution to journalArticle

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Abstract

MRI and morphological investigations into internal organ tissues and tumors in rats with liver cancer PC-1 under the intraperitoneal administration of magnetite hydrosols have been performed. The absence of any toxic effect of magnetite nanoparticles at low concentrations (0.325 mg/mL) has been determined using neutrophil granulocytes. A technique for the synthesis of citrate-stabilized magnetite hydrosols by the coprecipitation of Fe2+ and Fe3+ salts is described. Their electrokinetic potential is -32 ± 2 mV at pH 6.5 ± 0.1. The size distribution of magnetite nanoparticles is obtained by dynamic light scattering. The average size of magnetite nanoparticles is 23 ± 6 nm. The absorption spectra of magnetite hydrosols have been measured. The dependence of the optical density on the concentration has also been obtained. Molar absorption coefficients of magnetite nanoparticles have been calculated at the following wavelengths: 532, 633, 660, and 785 nm.

Original languageEnglish
Pages (from-to)573-580
Number of pages8
JournalNanotechnologies in Russia
Volume8
Issue number7-8
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Fingerprint

Magnetite Nanoparticles
Ferrosoferric Oxide
Magnetite nanoparticles
Magnetite
magnetite
Magnetic resonance imaging
Tissue
synthesis
nanoparticles
Density (optical)
Poisons
Dynamic light scattering
Coprecipitation
Citric Acid
Liver
Rats
Tumors
Absorption spectra
neutrophils
Salts

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Science(all)
  • Engineering(all)

Cite this

Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation. / German, S. V.; Inozemtseva, O. A.; Navolokin, N. A.; Pudovkina, E. E.; Zuev, V. V.; Volkova, E. K.; Bucharskaya, A. B.; Pleskova, S. N.; Maslyakova, G. N.; Gorin, D. A.

In: Nanotechnologies in Russia, Vol. 8, No. 7-8, 07.2013, p. 573-580.

Research output: Contribution to journalArticle

German, SV, Inozemtseva, OA, Navolokin, NA, Pudovkina, EE, Zuev, VV, Volkova, EK, Bucharskaya, AB, Pleskova, SN, Maslyakova, GN & Gorin, DA 2013, 'Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation', Nanotechnologies in Russia, vol. 8, no. 7-8, pp. 573-580. https://doi.org/10.1134/S1995078013040034
German, S. V. ; Inozemtseva, O. A. ; Navolokin, N. A. ; Pudovkina, E. E. ; Zuev, V. V. ; Volkova, E. K. ; Bucharskaya, A. B. ; Pleskova, S. N. ; Maslyakova, G. N. ; Gorin, D. A. / Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation. In: Nanotechnologies in Russia. 2013 ; Vol. 8, No. 7-8. pp. 573-580.
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