Synthesis of magnetic silica nanomarkers with controlled physicochemical properties

I. V. Zelepukin, M. P. Nikitin, V. R. Cherkasov, P. I. Nikitin, S. M. Deyev, P. V. Petrov

Research output: Contribution to journalArticle

Abstract

Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.

Original languageEnglish
Pages (from-to)335-337
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume470
Issue number1
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

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Ferrosoferric Oxide
Zeta potential
Silicon Dioxide
Limit of Detection
Polymers
carboxymethyl dextran

ASJC Scopus subject areas

  • Biophysics
  • Chemistry(all)
  • Medicine(all)
  • Biochemistry

Cite this

Synthesis of magnetic silica nanomarkers with controlled physicochemical properties. / Zelepukin, I. V.; Nikitin, M. P.; Cherkasov, V. R.; Nikitin, P. I.; Deyev, S. M.; Petrov, P. V.

In: Doklady Biochemistry and Biophysics, Vol. 470, No. 1, 01.09.2016, p. 335-337.

Research output: Contribution to journalArticle

Zelepukin, I. V. ; Nikitin, M. P. ; Cherkasov, V. R. ; Nikitin, P. I. ; Deyev, S. M. ; Petrov, P. V. / Synthesis of magnetic silica nanomarkers with controlled physicochemical properties. In: Doklady Biochemistry and Biophysics. 2016 ; Vol. 470, No. 1. pp. 335-337.
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