Abstract
A new method for obtaining biomodified magnetite nanoparticles for targeted delivery to cells was developed. The method is based on the use of the C-terminal fragment of the Mms6 protein, which is involved in the magnetite biomineralization during the synthesis of magnetosomes in magnetotactic bacteria Magnetospirillum magneticum AMB-1, and the barnase*barstar high-affinity protein pair. The Mms6 protein fragment is required for stabilizing magnetite, and the barnase*barstar pair mediates the interaction between nanoparticles and the component for modification. The efficiency of this method was confirmed in the synthesis of magnetite nanoparticles recognizing the HER2/neu tumor marker and in the selective labeling of HER2/neu with these nanoparticles on the surface of cancer cells.
Original language | English |
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Pages (from-to) | 198-200 |
Number of pages | 3 |
Journal | Doklady Biochemistry and Biophysics |
Volume | 481 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jul 2018 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Chemistry(all)