Synthesis of Magnetic Nanoparticles Stabilized by Magnetite-Binding Protein for Targeted Delivery to Cancer Cells

P. A. Kotelnikova, V. O. Shipunova, U. F. Aghayeva, O. A. Stremovskiy, M. P. Nikitin, I. A. Novikov, A. A. Schulga, S. M. Deyev, R. V. Petrov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A new method for obtaining biomodified magnetite nanoparticles for targeted delivery to cells was developed. The method is based on the use of the C-terminal fragment of the Mms6 protein, which is involved in the magnetite biomineralization during the synthesis of magnetosomes in magnetotactic bacteria Magnetospirillum magneticum AMB-1, and the barnase*barstar high-affinity protein pair. The Mms6 protein fragment is required for stabilizing magnetite, and the barnase*barstar pair mediates the interaction between nanoparticles and the component for modification. The efficiency of this method was confirmed in the synthesis of magnetite nanoparticles recognizing the HER2/neu tumor marker and in the selective labeling of HER2/neu with these nanoparticles on the surface of cancer cells.

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume481
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Chemistry(all)

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