Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes

Larissa B. Krasnova, Jason E. Hein, Valery V. Fokin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H) -ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.

Original languageEnglish
Pages (from-to)8662-8665
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number24
DOIs
Publication statusPublished - 17 Dec 2010
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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