Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes

Larissa B. Krasnova, Jason E. Hein, Valery V. Fokin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H) -ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.

Original languageEnglish
Pages (from-to)8662-8665
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number24
DOIs
Publication statusPublished - 17 Dec 2010
Externally publishedYes

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Alkynes
Copper
Isomers

ASJC Scopus subject areas

  • Organic Chemistry

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Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes. / Krasnova, Larissa B.; Hein, Jason E.; Fokin, Valery V.

In: Journal of Organic Chemistry, Vol. 75, No. 24, 17.12.2010, p. 8662-8665.

Research output: Contribution to journalArticle

Krasnova, Larissa B. ; Hein, Jason E. ; Fokin, Valery V. / Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes. In: Journal of Organic Chemistry. 2010 ; Vol. 75, No. 24. pp. 8662-8665.
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