Synthesis of 1,2,4-thiadiazoles by oxidative dimerization of carbothioamides by using oxone

Akira Yoshimura, Anthony D. Todora, Brent J. Kastern, Steven R. Koski, Viktor V. Zhdankin

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20 Citations (Scopus)


1,2,4-Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant. A similar reaction of phenylselenoamide led to the corresponding 1,2,4-phenylselenadiazole in high yield.

Original languageEnglish
Pages (from-to)5149-5152
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number24
Publication statusPublished - 1 Jan 2014
Externally publishedYes



  • Heterocycles
  • Oxidation
  • Oxone
  • Selenium
  • Sulfur

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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